Pyruvate dehydrogenase complex and lactate dehydrogenase are targets for therapy of acute liver failure

Acute liver failure is a rapidly progressive, life-threatening deterioration of liver function that results in altered neurological state and coagulopathy. The only treatment that improves the outcome of acute liver failure is emergency liver transplantation. Because liver transplantation has limitations related to invasiveness, limited donor availability and high mortality, therapies for acute liver failure are urgently needed.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Research Article Source Type: research