Alzheimer ’s Reversed By Asthma Drug (S)
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Conclusions:DORAs offer an additional treatment option for insomnia. More clinical trials are needed to robustly evaluate their safety and effectiveness in several subclasses of individuals with insomnia. Given the published literature, head-to-head comparisons to existing treatment for insomnia are warranted.Citation:Janto K, Prichard JR, Pusalavidyasagar S. An update on dual orexin receptor antagonists and their potential role in insomnia therapeutics.J Clin Sleep Med. 2018;14(8):1399–1408.
Publication date: Available online 14 August 2018Source: NeuroImage: ClinicalAuthor(s): Annegreet van Opbroek, Hakim C. Achterberg, Meike W. Vernooij, M. Arfan Ikram, Marleen de Bruijne, Alzheimer's Disease Neuroimaging InitiativeAbstractMany successful approaches in MR brain segmentation use supervised voxel classification, which requires manually labeled training images that are representative of the test images to segment. However, the performance of such methods often deteriorates if training and test images are acquired with different scanners or scanning parameters, since this leads to differences in feature represen...
DiscussionBBB breakdown is associated with cognitive decline. Cell adhesion, neutrophil migration, high-density lipoprotein metabolism, and angiogenesis are implicated.
ConclusionsThe inhibition of inflammasome/caspase-1 is one of key mechanisms of action in asthma. Some traditional recipes are active on this mechanism and are thus strong candidates for the treatment of asthma and other inflammasome-mediated diseases. Further investigations are needed to characterize active molecules.Graphical abstract
Publication date: Available online 14 August 2018Source: Dermatologica SinicaAuthor(s): Yuru Tang, Rui Wang, Xiao Gao, Dengbin AiAbstractPosterpetic neuralgia (PHN), a common and often severe painful condition, is a kind of refractory neuropathic pain (NP). Although the clinical treatment of PHN including pregabalin, nerve block and pulsed radiofrequency have been devoted with adequate and reasonable efforts, a proportion of people with PHN fail to obtain pain relief. Spinal cord stimulation (SCS) represents an adjustable and nondestructive procedure that considered electrical stimulation as the key mechanism for NP relief...
More insight into the eye as a'window into the brain'comes from a study linking glaucoma, age-related macular degeneration, and diabetic retinopathy to a higher risk for Alzheimer's disease.Medscape Medical News
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Conclusions Daily exercise reversed nociceptive sensitization, inflammation, anxiety, and memory loss after tibia fracture.
NEW GENES that may contribute to Alzheimer's disease have been identified by scientists.