Skeletal accumulation of fluorescently tagged zoledronate is higher in animals with early stage chronic kidney disease

ConclusionsThese results provide new data regarding how reduced kidney function affects drug accumulation in rat bone.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research

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You're reading The Starting Five: Vitamins for Improved Health, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. “By the proper intakes of vitamins and other nutrients…you can, I believe, extend your life and years of well-being by twenty-five or even thirty-five years,” said Nobel Prize winning scientist Linus Pauling. Modern research has confirmed Pauling’s belief as it has identified five vitamins that may improve overall health. Vitamin D Vitamin D provides many important health benefits. It ...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: featured health and fitness pickthebrain self improvement vitamins what vitamins should i take Source Type: blogs
Publication date: November–December 2018Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 6, Issue 6Author(s): Luke E. Barry, Ciaran O'Neill, Chris Patterson, Joan Sweeney, David Price, Liam G. HeaneyBackgroundTreatment of severe asthma may include high-dose systemic corticosteroid therapy, which is associated with substantial comorbidity. There is evidence to suggest that this burden is not evenly distributed across age, sex, and corticosteroid exposure levels.ObjectiveTo examine the associations between age, sex, comorbidity, and patterns of health care cost across groups differentiated by...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
AbstractPurpose of ReviewWe will review non-renal-related mechanisms of fibroblast growth factor 23 (FGF23) pathophysiology.Recent FindingsFGF23 production and metabolism may be affected by many bone, mineral, and kidney factors. However, it has recently been demonstrated that other factors, such as iron status, erythropoietin, and inflammation, also affect FGF23 production and metabolism. As these non-mineral factors are especially relevant in the setting of chronic kidney disease (CKD), they may represent emerging determinants of CKD-associated elevated FGF23 levels. Moreover, FGF23 itself may promote anemia and inflamma...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
AbstractPurpose of ReviewPatients with chronic kidney disease (CKD) have a greatly increased fracture risk compared with the general population. Gonadal hormones have an important influence on bone mineral density (BMD) and fracture risk, and hormone therapies can significantly improve these outcomes. Gonadal dysfunction is a frequent finding in patients with CKD; yet, little is known about the impact of gonadal hormones in the pathogenesis and treatment of bone health in patients with CKD. This systematic review and meta-analysis aimed to examine the effects of gonadal hormones and hormone therapies on bone outcomes in me...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
Publication date: Available online 10 October 2018Source: Pharmacological ResearchAuthor(s): Xufeng Tao, Lianhong Yin, Lina Xu, Jinyong PengAbstractCurrently, the numbers of patients with cancer, fibrosis, diabetes, chronic kidney disease, stroke and osteoporosis are increasing fast and fast. It’s critical necessary to discovery lead compounds for new drug development. Dioscin, one active compound in some medicinal plants, has anti-inflammation, immunoregulation, hypolipidemic, anti-viral, anti-fungal and anti-allergic effects. In recent years, dioscin has reached more and more attention with its potent effects to tr...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
ConclusionsThese results suggest a role for FGF23/klotho axis on bone and vascular metabolism in dialysis populations.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
Conclusion: Herein, we present a case of infantile hypercalcemia 2 with a very different phenotype from that of previously described patients. Our findings provide further evidence for the wide range of phenotypic heterogeneity associated with NaPi-IIa impairment.Horm Res Paediatr
Source: Hormone Research in Paediatrics - Category: Endocrinology Source Type: research
This study assessed the risk factors for reduced cCa concentration following denosumab administration and anal yzed factors predictive of changes in bone mineral density (BMD).MethodsSeventy-seven osteoporotic patients, not including those with CKD stages 4 –5D, were treated with 60 mg denosumab once every 6 months. Biochemical parameters and BMD were analyzed from prior to the initial dose until 1 month after the second dose.ResultsFollowing the first administration of denosumab, cCa levels decreased, reaching a minimum on day 7. Multiple linear regression analyses showed that baseline cCa, estimated ...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
Mineral bone disease (MBD) is a common complication of chronic kidney disease (CKD) characterized by disruption of normal mineral homeostasis within the body. One or more of the following may occur: hypocalcemia, hyperphosphatemia, secondary hyperparathyroidism (SHPT), decreased vitamin D and vascular calcification (VC). The greater the decrease in renal function, the worse the progression of CKD-MBD. These abnormalities may lead to bone loss, osteoporosis and fractures. CKD-MBD is a major contributor to the high morbidity and mortality among patients with CKD.
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Review article Source Type: research
AbstractSummaryOsteoporosis has become an important health concern even in men. We aimed to analyze its prevalence and associated factors in Korean men. Low socioeconomic status, unhealthy lifestyle, and chronic kidney disease increased the risk. High-risk men even at young age need to evaluate bone mineral density, and proper interventions should be reinforced.PurposeOwing to an increase in the elderly population, osteoporosis and consequent fractures have become important health concerns even in men. We aimed to analyze the prevalence of osteoporosis in Korean men and identify risk factors associated with male osteoporos...
Source: Archives of Orthopaedic and Trauma Surgery - Category: Orthopaedics Source Type: research
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