Osteopontin attenuates inflammation via JAK2/STAT1 pathway in hyperglycemic rats after intracerebral hemorrhage.

In conclusion, rOPN attenuated ICH-induced brain inflammation in hyperglycemic rats, leading to attenuation of brain edema and improving neurological functions. Effects of rOPN were mediated at least partly by integrin-β1 induced inhibition of JAK2/STAT1 pathway. PMID: 29885817 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29885817?dopt=Abstract

Source: Neuropharmacology - June 7, 2018 Category: Drugs & Pharmacology Authors: Gong L, Manaenko A, Fan R, Huang L, Enkhjargal B, McBride D, Ding Y, Tang J, Xiao X, Zhang JH Tags: Neuropharmacology Source Type: research