Renal function and acute heart failure outcome.

Renal function and acute heart failure outcome. Med Clin (Barc). 2018 Jun 05;: Authors: Llauger L, Jacob J, Miró Ò Abstract The interaction between acute heart failure (AHF) and renal dysfunction is complex. Several studies have evaluated the prognostic value of this syndrome. The aim of this systematic review, which includes non-selected samples, was to investigate the impact of different renal function variables on the AHF prognosis. The categories included in the studies reviewed included: creatinine, blood urea nitrogen (BUN), the BUN/creatinine quotient, chronic kidney disease, the formula to estimate the glomerular filtration rate, criteria of acute renal injury and new biomarkers of renal damage such as neutrophil gelatinase-associated lipocalin (NGAL and cystatin c). The basal alterations of the renal function, as well as the acute alterations, transient or not, are related to a worse prognosis in AHF, it is therefore necessary to always have baseline, acute and evolutive renal function parameters. PMID: 29884452 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research

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Conclusion Time-varying kidney function is not independently related to poor prognosis in HF. Rather than directly affecting survival, renal impairment is probably a surrogate marker of HF severity. Teaser Renal impairment has been considered a negative prognostic factor in heart failure (HF). The evidence comes from studies investigating the role of baseline kidney function (KF) or comparing KF and worsening renal function at different time points. We studied the impact of KF on long term prognosis of ambulatory HF patients, taking into account its time-varying effect. We found an association between poorer KF over time a...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Authors: Ruge T, Carlsson AC, Ingelsson E, Risérus U, Sundström J, Larsson A, Lind L, Ärnlöv J Abstract OBJECTIVE: Circulating levels of endostatin are elevated in many underlying conditions leading to heart failure such as hypertension, diabetes, chronic kidney disease and ischemic heart disease. Yet, the association between endostatin and the incidence of heart failure has not been reported previously in the community. DESIGN: We investigated the longitudinal association between serum endostatin levels and incident heart failure in two community-based cohorts of elderly: Prospective Inve...
Source: Scandinavian Cardiovascular Journal - Category: Cardiology Tags: Scand Cardiovasc J Source Type: research
Conclusions Adults with CKD and higher circulating GDF-15, Gal-3, and sST2 concentrations experienced greater mortality. Elevated GDF-15 concentration was also associated with an increased rate of heart failure. Further work is needed to elucidate the mechanisms linking these circulating biomarkers with CVD in patients with CKD.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
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Source: Journal of Comparative Effectiveness Research - Category: General Medicine Tags: J Comp Eff Res Source Type: research
Conclusions Harmony Outcomes will assess the CV safety of albiglutide in patients with T2DM and CV disease. Trials of other agents in the GLP-1 RA class have shown CV benefit for only some of these medications, possibly due to differences in trial design or instead due to differences in drug structure or metabolism. Harmony Outcomes will provide information critical to our understanding of this heterogenous class of glucose-lowering agents.
Source: American Heart Journal - Category: Cardiology Source Type: research
This study aimed to validate the accuracy of major-event risk models created in the multicenter J-ACCESS prognostic study in a new cohort of patients with chronic kidney disease (CKD).Methods and ResultsThree multivariable J-ACCESS risk models were created to predict major cardiac events (cardiac death, non-fatal acute coronary syndrome, and severe heart failure requiring hospitalization): Model 1, four variables of age, summed stress score, left ventricular ejection fraction and diabetes; Model 2 with five variables including estimated glomerular filtration rate (eGFR, continuous); and Model 3 with categorical eGFR. The v...
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
Thirty years after the formulation of the neurohormonal hypothesis by Milton Packer [1], implementation and adherence to therapy for antagonism of neurohormonal overactivity in heart failure (HF) remains one of the greatest challenge in cardiology [2]. One cornerstone of HF therapy is represented by renin-angiotensin system (RAS) blockade either with angiotensin-converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB). Up-to-date, however, a significant number of HF patients does not receive any RAS blocker, while in several the target dose is not attained, and this frequently occurs because of an unjusti...
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
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Source: Cardiovascular Drugs and Therapy - Category: Cardiology Source Type: research
Conclusions Adjusted for key confounders, BIA-derived measures of cellular integrity and tissue hydration were significantly associated with death and incident heart failure, respectively.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Conclusions Lower calcitriol concentrations are independently associated with kidney function decline in community-living older adults. Future studies will be needed to clarify whether these associations reflect lower calcitriol concentrations resulting from abnormal kidney tubule dysfunction or direct mechanisms relating lower calcitriol concentrations to more rapid loss of kidney function.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
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