Crosstalk between type I and II interferons in regulation of myeloid cell responses during bacterial infection.

Crosstalk between type I and II interferons in regulation of myeloid cell responses during bacterial infection.
Curr Opin Immunol. 2018 Jun 07;54:35-41
Authors: Crisler WJ, Lenz LL
Abstract
Type I and type II interferons (IFNα/β and IFNγ) are cytokines that play indispensable roles in directing myeloid cell activity during inflammatory and immune responses. Each IFN type binds a distinct receptor (IFNAR or IFNGR) to transduce signals that reshape gene expression and function of myeloid and other cell types. In the context of murine models and human bacterial infections, production of IFNγ generally promotes resistance while production of IFNα/β is associated with increased host susceptibility. Here, we review mechanisms of crosstalk between type I and II IFNs in myeloid cells and their impact on myeloid cell activation and anti-microbial function.
PMID: 29886270 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - June 7, 2018 Category: Allergy & Immunology Authors: Crisler WJ, Lenz LL Tags: Curr Opin Immunol Source Type: research