Distinct Clinical Features and Outcomes in Motor Neuron Disease Associated with Behavioural Variant Frontotemporal Dementia.
CONCLUSIONS: The MND-FTD patients frequently displayed a distinctive motor pattern characterized by weakness and atrophy in distal upper limb muscles and dysphagia, with no or little spreading to other regions. These features may help to define specific subgroups of patients, which is important with regard to clinical management, outcome, and research. PMID: 29886477 [PubMed - as supplied by publisher]
We examined differences in dementia risk between low-educated non-Hispanic whites, Hispanics, and African Americans, and the impact of lifetime risk factors using data from the nationally representative Aging, Demographics, and Memory Study (N = 819). RESULTS: As indicated by Cox regression modeling, dementia risk of low-educated individuals was not significantly different between ethnic groups but was related to having an APOE e4 allele (hazard ratio [HR] 1.89), depression (HR 1.67), stroke (HR 1.60), and smoking (HR 1.32). Further, even in people with low education, every additional year of education de...
CONCLUSIONS: The development of a dedicated paediatric surgery service and the implementation of management protocols have resulted in excellent outcomes for this problem. PMID: 30004364 [PubMed - in process]
Conclusions: In the Polish setting, in selected patients, management of high- and intermediate-risk pulmonary embolism with PMPT is technically feasible. Such treatment is relatively safe and effective. It can be an alternative to standard management, especially in patients with contraindications for fibrinolysis or surgical embolectomy. PMID: 30002757 [PubMed]
We presently forget 98% of everything we experience. That will go away in favor of perfect, controllable, configurable memory. Skills and knowledge will become commodities that can be purchased and installed. We will be able to feel exactly as we wish to feel at any given time. How we perceive the world will be mutable and subject to choice. How we think, the very fundamental basis of the mind, will also be mutable and subject to choice. We will merge with our machines, as Kurzweil puts it. The boundary between mind and computing device, between the individual and his or her tools, will blur. Over the course of the ...
New research offers 'the first population evidence for a causal link' between herpes infection and the development of Alzheimer's disease.
Respiratory syncytial virus (RSV) is one of the most common etiological agents of acute respiratory infections (ARI) among children such as bronchiolitis and pneumonia [1,2]. RSV can be divided into two subgroups (A and B) that commonly produce annual epidemics characterized by the circulation of several genotypic strains . The seasonality of RSV-A and RSV-B can be markedly different . Virus-specific molecular assays such as real-time polymerase chain reaction (RT-PCR) are now considered the gold standard in the diagnosis of viral respiratory tract infections.
Antipsychotic medications are the cornerstone of schizophrenia treatment, but are used in a range of other psychiatric conditions, including dementia. Prescribing such drugs to older people is common, particularly in care home residents , and potentially risky . Much antipsychotic use in the elderly is off-label. There is a paucity of evidence about their efficacy, mostly extrapolated from data in younger adults. Side effects of antipsychotics are diverse and are known to affect adherence.
The Hospital Readmissions Reduction Program (HRRP) has been associated with substantial reductions in readmission within 30 days of discharge among fee-for-service Medicare beneficiaries aged ≥65 years who are hospitalized with acute myocardial infarction, heart failure, or pneumonia – the target population for this program.1,2 There have been suggestions that hospitals may have pursued reductions in readmissions through efforts mainly directed towards Medicare beneficiaries aged ≥ 65 years without pursuing systematic improvements in the care of patients.
Dear Carol: I’ve lived 900 miles away from my parents for years. My husband and I were tied down with caring for his parents, so we didn’t see my family as often as we’d like, but they always seemed fine when we talked or visited. Now, his parents have both passed and we’ve been traveling to visit my parents more often. These last few visits have highlighted my mom’s decline. It’s obvious that she’s got dementia but she ignores the symptoms and hasn't been diagnosed. Dad is in denial and covers for her, as does my only sibling. How do I even begin to help with this? – NY...
Falls in older adults are common and debilitating. In the US alone, costs related to falls amounted to over 31 billion dollars; fall-related injury is among the top 20 most expensive medical conditions (1). One of the most serious fall injuries is hip fracture, seen in over 300,000 older adults yearly in the US (2). Hip fracture occurs more frequently in women, older adults, those with frailty associated with lower bone density (3), and those with neurodegenerative brain diseases such as Alzheimer's dementia (4).