Distinct Clinical Features and Outcomes in Motor Neuron Disease Associated with Behavioural Variant Frontotemporal Dementia.
CONCLUSIONS: The MND-FTD patients frequently displayed a distinctive motor pattern characterized by weakness and atrophy in distal upper limb muscles and dysphagia, with no or little spreading to other regions. These features may help to define specific subgroups of patients, which is important with regard to clinical management, outcome, and research. PMID: 29886477 [PubMed - as supplied by publisher]
DEMENTIA is a term used to describe different degenerative diseases which affect the brain. There ’s currently no cure, and scientists are unsure of the exact causes of the condition, but a new study has found a simple blood test could detect symptoms 16 years before they’re first noticed.
Many people aren't getting enough sleep, and the consequences are far more serious than feeling dozy and worn out. New research indicates it can affect your ability to form long-term memories and retain things you learn, and may even have an impact on dementia.
Zoe Butti, Shunmoogum A. Patten
Introduction: HIV-associated neurocognitive deficit (HAND) has a prevalence of 30-50% in people living with HIV with commonly affected cognitive domains being learning, memory, and executive function.1 Pharmacological treatments such using combination antiretroviral therapy (cART) have nearly eliminated the most severe form of HAND, HIV- associated Dementia, however milder forms of cognitive impairment still occur.1,2,3 Despite viral load suppression, HAND does not improve with traditional therapy.
Currently, no effective intervention exists for people at increased risk for dementia. While recent reviews have highlighted promising results for cognitive training (CT), randomized controlled trials (RCTs) in people diagnosed with mild cognitive impairment (MCI) have shown modest efficacy for memory improvement. Transcranial direct current stimulation (tDCS) is a safe, non-invasive technique, which can enhance cognitive functioning.
Ageing is a major predicting risk factor for dementia and no treatment is currently available for this disorder. Although promising outcome has been reported for electrical stimulation on dementia, the molecular mechanisms still remain obscure. In an aged rat model, our results demonstrate that both entorhinal and perifornical stimulation enhanced spatial memory in the Morris water-maze without affecting anxiety levels. The microarray profiling showed a total of 1514 and 321 coding genes differentially expressed in the hippocampus, with a distinct pattern of signaling mechanisms involving the neurotransmission and neuropla...
Background: New imaging techniques suggest an involvement of the motor corpus callosum (CC) in amyotrophic lateral sclerosis (ALS) (Agosta et al., 2010; Unrath et al., 2011; Kassubek et al., 2012). Yet, a functional involvement can not easily be shown only by the means of magnetic resonance imaging or fibre tracking. Our goal was to demonstrate functional deficits of the motor CC in ALS using transcranial magnetic stimulation (TMS).
Amyloid-beta (A β) and phosphorylated-Tau (pTau) proteins in cerebrospinal fluids (CSF) are known as the most reliable biomarker for early and preclinical staged Alzheimer’s disease (AD).
As many as 50% of demented patients are agitated at some point during their illness and up to a third may became physically aggressive toward caregivers. First-line treatment approaches for behavioral disturbances in dementia are psychosocial and not pharmacological. Pharmacological interventions are second line, but the use of most medications is off label and complicated by potentially serious side effects. There is an absence of evidence-based data as to the use of ECT to treat refractory behavioral disturbances in dementia, although a large body of case reports and case series points to its possible safety and efficacy.
Mild cognitive impairment (MCI) is considered a phase between the usual cognitive decline of aging and the marked cognitive decline linked to dementia. Cognitive training (CT) is one strategy used to slow down the cognitive deterioration for persons with MCI. It has been proposed that tDCS could be paired with CT to boost its remedial effects. Targeting neural circuits using tDCS, that are simultaneously engaged in CT exercises may generate better therapeutic outcomes.