Antibiotic resistance could be countered by anti-bacterial viruses

Research found some patients had lower E coli levels after being given cocktail of ‘phages’Viruses that invade bacteria but leave human cells alone could help scientists find ways around the growing problem of antibiotic resistance, researchers have said. A study has showed that a cocktail of bacteriophages, or “phages”, resulted in no side effects when given to individuals with gastrointestinal problems and did not appear to greatly disrupt the diversity of microbes in the gut – the so-calledgut microbiota. But they did reduce levels of one marker of inflammation and certain problematic species of bacteria.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Antibiotics Medical research Science Society Biology UK news Health Source Type: news

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Publication date: Available online 19 January 2019Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular BiologyAuthor(s): Chongyuan Lin, Mengdi Liu, Xiaojing Zhu, Mengmeng Zhang, Shanliang Xu, Danli Wang, Yunlong ZhaoAbstractThe activity of NAD+-dependent deacetylase Sir2, originally discovered in yeast, is known to be essential for effective longevity. The relationship between Sir2 and lifespan in Daphnia pulex was investigated by cloning and analysis the full-length 1901 bp cDNA. The Sir2 protein includes several zinc finger active sites and two readily hydrolysable low-complexity SD-rich r...
Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology - Category: Molecular Biology Source Type: research
Publication date: 15 April 2019Source: Chemical Engineering Journal, Volume 362Author(s): Hongkun Ma, Lingling Zhang, Xinmei Huang, Wei Ding, Hui Jin, Zifu Li, Shikun Cheng, Lei ZhengAbstractA novel and efficient three-dimensional electrode galvanic cell enhanced Fe2+/persulfate (3D-GFP) system was used to inactivate antibiotic resistant E. coli (AR E. coli) for the first time. The 3D-GFP system was compared with two-dimensional electrode GFP. The 3D-GDP system obviously had a better disinfection effect than the 2D electrode GDP and achieved a 4.6 log disinfection of bacteria within 10 min. Several disinfection experimen...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
CONCLUSIONS: The therapeutic use of metronidazole had increased worldwide. Even though it is widely used, metronidazole has been associated with neurotoxicity and genotoxicity; however, its side effects are not well established. Conversely, its veterinary use is restricted in some countries because of its tumor association. Subsequently, further studies are needed to discover the secure use of metronidazole and describe new usages for this drug. PMID: 30657582 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
ConclusionWe propose that the commensal intestinal microbiota of free-ranging Baird’s tapirs in this area remains isolated from antibiotic selective pressure, probably because seven different protected areas converge, thus giving a possible low anthropogenic activity to the region.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: Available online 19 January 2019Source: Comparative Immunology, Microbiology and Infectious DiseasesAuthor(s): A. Prisilla, P. ChellapandiAbstractC2 toxin produced from Clostridium botulinum serotypes C and D has a potential role in many pathophysiological mechanisms in birds and animals. It has encompassed an ADP ribosyltransferase subunit (C2I) and a translocation/binding subunit (C2II). In the present study, we intended to produce C2I mutant proteins as recombinant subunit vaccines by using glutathione-S-transferase-gene fusion system. The mutants of this study were previously evaluated from their evol...
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
Publication date: Available online 19 January 2019Source: Comparative Immunology, Microbiology and Infectious DiseasesAuthor(s): Mario Cervone, Alessandra Gavazza, Alina Zbriger, Francesca Mancianti, Stefania PerrucciAbstractPrevalence and species composition of intestinal parasites were evaluated in dogs affected by high-grade multicentric lymphoma and undergoing chemotherapy and in control healthy dogs. Obtained data were statistically analyzed. The overall prevalence of intestinal parasite infections was 33.3%. In lymphoma dogs, the prevalence of protozoa infections (46.7%) was significantly higher (p 
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
ConclusionInhibiting CTGF could improve inflammatory response and intestinal flora to partially reverse DSS-induced UC via blocking ERK signaling pathway.Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 19 January 2019Source: Materials Science and Engineering: CAuthor(s): Zhiyong Song, Yang Wu, Huajuan Wang, Heyou HanAbstractDue to their remarkable antibacterial properties, silver nanoparticles (Ag NPs) and curcumin (CCM) have been widely used in the antimicrobial field. In our study, we have fabricated the uniform and stable silver/curcumin composite nanoparticles by a facile ultrasound treatment process and the synergistic antibacterial activity were evaluated. The curcumin not only played a role of reducing agent but also acted as a capping agent. The antibacterial effects of silver/c...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 18 January 2019Source: Journal of Molecular BiologyAuthor(s): Seán M. Murray, Martin HowardAbstractWe review the key role played by mathematical modelling in elucidating two centre-finding patterning systems in E. coli: midcell division positioning by the MinCDE system and DNA partitioning by the ParABS system. We focus particularly on how, despite much experimental effort, these systems were simply too complex to unravel by experiments alone, and instead required key injections of quantitative, mathematical thinking. We conclude the review by analysing the frequency of modelling a...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
Authors: Mehr S, Campbell DE Abstract Food protein-induced enterocolitis syndrome (FPIES) is a poorly understood non-IgE gastrointestinal-mediated food allergy that predominantly affects infants and young children. Cells of the innate immune system appear to be activated during an FPIES reaction. Acute FPIES typically presents between one and 4 hours after ingestion of the trigger food, with the principal symptom being profuse vomiting, and is often accompanied by pallor and lethargy. Additional features can include hypotension, hypothermia, diarrhoea, neutrophilia and thrombocytosis. In Australia, the most commonl...
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
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