Antibiotic resistance could be countered by anti-bacterial viruses

Research found some patients had lower E coli levels after being given cocktail of ‘phages’Viruses that invade bacteria but leave human cells alone could help scientists find ways around the growing problem of antibiotic resistance, researchers have said. A study has showed that a cocktail of bacteriophages, or “phages”, resulted in no side effects when given to individuals with gastrointestinal problems and did not appear to greatly disrupt the diversity of microbes in the gut – the so-calledgut microbiota. But they did reduce levels of one marker of inflammation and certain problematic species of bacteria.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Antibiotics Medical research Science Society Biology UK news Health Source Type: news

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CONCLUSIONS: Almost half of the theatre staff carried S. aureus isolates on their hands prior to handwashing and approximately one-third after handwashing. Closer monitoring of handwashing techniques should be introduced. PMID: 30004326 [PubMed - in process]
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research
ConclusionsBy highlighting the conserved structural and functional domains of LDH from two entirely different species, this study has graded potential inhibitory molecules on the basis of their binding affinities so that they can be applied for in vivo anticancer studies.
Source: Electronic Journal of Biotechnology - Category: Biotechnology Source Type: research
Publication date: 1 July 2018Source: Methods, Volume 143Author(s): Colin S. Maxwell, Thomas Jacobsen, Ryan Marshall, Vincent Noireaux, Chase L. BeiselAbstractThe RNA-guided nucleases derived from the CRISPR-Cas systems in bacteria and archaea have found numerous applications in biotechnology, including genome editing, imaging, and gene regulation. However, the discovery of novel Cas nucleases has outpaced their characterization and subsequent exploitation. A key step in characterizing Cas nucleases is determining which protospacer-adjacent motif (PAM) sequences they recognize. Here, we report advances to an in vitro method...
Source: Methods - Category: Molecular Biology Source Type: research
Publication date: 1 July 2018Source: Methods, Volume 143Author(s): Asuka A. Orr, Juan C. Gonzalez-Rivera, Mark Wilson, P. Reena Bhikha, Daiqi Wang, Lydia M. Contreras, Phanourios TamamisAbstractThere are over 150 currently known, highly diverse chemically modified RNAs, which are dynamic, reversible, and can modulate RNA-protein interactions. Yet, little is known about the wealth of such interactions. This can be attributed to the lack of tools that allow the rapid study of all the potential RNA modifications that might mediate RNA-protein interactions. As a promising step toward this direction, here we present a computati...
Source: Methods - Category: Molecular Biology Source Type: research
Conclusion: Clinical findings become indistinct by age, and differential diagnosis of abdominal pain gets more difficult in geriatric patients. Therefore, physicians should consider age related physiological changes in order to distinguish geriatric patients admitted to emergency service with abdominal pain from pathological cases requiring immediate surgical operation. PMID: 30002677 [PubMed]
Source: Current Gerontology and Geriatrics Research - Category: Geriatrics Tags: Curr Gerontol Geriatr Res Source Type: research
Publication date: Available online 11 May 2018Source: Materials Chemistry and PhysicsAuthor(s): Emilia Zachanowicz, Jacek Pigłowski, Aleksander Zięcina, Krzysztof Rogacki, Błażej Poźniak, Marta Tikhomirov, Monika Marędziak, Krzysztof Marycz, Joanna Kisała, Kinga Hęclik, Robert PązikAbstractPolymeric hybrid materials were synthesized via chemical oxidation polymerization. Process was carried on the surface of the magnetic nanoparticles, (prepared separately) where the initiator (Fe3+ ions) was located. The structure of the resulting nanocomposite was investigated in detail by means of X-ray diffraction (XRD) and Fo...
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research
Publication date: 10 September 2018Source: Journal of Biotechnology, Volume 281Author(s): Qi Chen, Shaofei Zhang, Yunchang XieAbstractThe enzymatic Pictet-Spengler (PS) reaction, catalyzed by Pictet-Spenglerase (PSase), is the feature of β-carboline (βC) alkaloid biosynthesis. NscbB is a rare microbial PSase discovered from a cryptic β-carboline alkaloid biosynthetic gene cluster (BGC) in the Nocardiopsis synnemataformans DSM 44143 (kidney transplant patient derived) by homologous alignment with its well-characterized counterpart McbB. The biochemical analysis showed that NscbB could catalyze l-tryptophan (K...
Source: Journal of Biotechnology - Category: Biotechnology Source Type: research
Publication date: Available online 30 June 2018Source: Journal of Molecular LiquidsAuthor(s): Paweł Kowalczyk, Andrzej Borkowski, Grzegorz Czerwonka, Tomasz Cłapa, Jolanta Cieśla, Anna Misiewicz, Marta Borowiec, Mateusz SzalaAbstractIn the present study the toxicity of theophylline-based quaternary alkylammonium ionic liquids and their precursors was investigated in relation to smooth and rough Escherichia coli strains. We assumed that the microbial toxicity of the studied amphiphilic compounds was affected by the composition of the lipopolysaccharide (LPS) of Gram-negative bacteria. Our hypothesis was verified using K-...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Conclusions: Our data showed that the detection rate of astrovirus in diarrheal children (18.87%) was higher than observed in other countries, where they were reported in diarrheal children in 10.3%–0.8% of patients and a mean incidence worldwide of 11%. Our data showed that the detection rate of astrovirus in pediatric gastroenteritis was greater than previously reported in Italy.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
Conclusions: Inhibition of E. coli binding to endothelial cell αVβ3 by cilengitide prevents endothelial dysfunction and may, therefore, present as a novel early therapeutic for the treatment of sepsis.
Source: Critical Care Medicine - Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research
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