Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy.

In conclusion, our findings disclose defective receptor signaling related to impaired mitochondrial bioenergetics, independent of apoptosis, in platelets from cancer patients treated with chemotherapy, explaining the low hemostatic potential of these patients. PMID: 29880611 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29880611?dopt=Abstract

Source: Haematologica - June 7, 2018 Category: Hematology Authors: Baaten CCFMJ, Moenen FCJI, Henskens YMC, Swieringa F, Wetzels RJH, van Oerle R, Heijnen HFG, Ten Cate H, Holloway GP, Beckers EAM, Heemskerk JWM, van der Meijden PEJ Tags: Haematologica Source Type: research