Fatty Mesenteric Lymphadenopathy: What Does It Mean?

Question: A 56-year-old man with celiac disease presented to the emergency room with intermittent fever for the last month. There was no history of cough, urinary symptoms, or abdominal pain. He had a recent right colectomy for adenocarcinoma. His physical examination was unremarkable. Laboratory investigation showed anemia, and negative blood and urine cultures. Initial investigation with a postcontrast computed tomography scan of the abdomen showed multiple, coalescent, rim-enhancing, round cystic lesions with low-attenuation in the root of the small bowel mesentery (Figure A, arrows); some of them showed fat attenuation (Figure A, arrowheads).
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Clinical Challenges and Images in GI Source Type: research

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Hereditary hemorrhagic telangiectasia (HHT), a genetic bleeding disorder leading to systemic arteriovenous malformations (AVMs), is caused by loss-of-function mutations in the ALK1/ENG/Smad1/5/8 pathway. Evidence suggests that HHT pathogenesis strongly relies on overactivated PI3K/Akt/mTOR and VEGFR2 pathways in endothelial cells (ECs). In the BMP9/10-immunoblocked (BMP9/10ib) neonatal mouse model of HHT, we report here that the mTOR inhibitor, sirolimus, and the receptor tyrosine kinase inhibitor, nintedanib, could synergistically fully block, but also reversed, retinal AVMs to avert retinal bleeding and anemia. Sirolimus...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Signaling by the TGF-β superfamily is important in the regulation of hematopoiesis and is dysregulated in myelodysplastic syndromes (MDSs), contributing to ineffective hematopoiesis and clinical cytopenias. TGF-β, activins, and growth differentiation factors exert inhibitory effects on red cell formation by activating canonical SMAD2/3 pathway signaling. In this Review, we summarize evidence that overactivation of SMAD2/3 signaling pathways in MDSs causes anemia due to impaired erythroid maturation. We also describe the basis for biological activity of activin receptor ligand traps, novel fusion proteins such as ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Publication date: 15 May 2020Source: Journal of Alloys and Compounds, Volume 823Author(s): Jinzhi Jia, Xu Dong Liu, Xiaojia Li, Linhong Cao, Meng Zhang, Botao Wu, Xiuwen ZhouAbstractThe morphology and size of nanostructures have been considered to be directly related to capacitive performance. Additionally, hydrothermal synthesis is a common method to control nanostructures. In practice, researchers paid more attention to the direct effect of “useful ions” on morphology or size of nanostructures, e.g. the combination and decomposition processes of H+ and WO42− to form WO3. Unfortunately, the effects of ot...
Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
Publication date: 15 May 2020Source: Journal of Alloys and Compounds, Volume 823Author(s): Stephan Laube, Hans Chen, Alexander Kauffmann, Steven Schellert, Franz Müller, Bronislava Gorr, Julian Müller, Benjamin Butz, Hans-Juergen Christ, Martin HeilmaierAbstractRefractory high entropy alloys (RHEAs) from the Mo–Cr–Ti–Al system exhibit promising strength at elevated temperatures. However, at room temperature they possess a B2-ordered crystal structure and, therefore, exhibit reduced ductility. Guided by thermodynamic calculations, the Al concentration was systematically reduced in MoCrTi-xAl (x&n...
Source: Journal of Alloys and Compounds - Category: Chemistry Source Type: research
Authors: Ertel KA, Hallam JE, Hillman AR Abstract BACKGROUND: Individuals participating in exercise beyond their level of fitness may be at higher risk for exercise-induced muscle damage, however the impact of training status on muscle damage development is not well understood. The purpose of this study was to measure skeletal muscle damage and soreness after five days of high and low intensity exercise in previously trained and untrained individuals. METHODS: Eighteen males and females (9 trained and 9 untrained) completed five consecutive days of high intensity (HI) exercise and five consecutive days of low i...
Source: Journal of Sports Medicine and Physical Fitness - Category: Sports Medicine Tags: J Sports Med Phys Fitness Source Type: research
I haven't used Stimwave since fellowship. Anyone using their technology for peripheral nerve stim? Results? Pros/Cons and feedback from patients? If I were going to use it, it would probably be for suprascapular neuralgia, genicular nerualgia, and/or SI joint pain vs cluneal neuralgia, when other options have failed (i.e. RF).
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
How bad of an idea is it to be pregnant with adequate lead coverage during early months of pregnancy? I had a fellow resident who was pregnant who changed her rotations around to avoid any exposure, however it's my understanding that overall the exposure with adequate coverage is ultimately fine. I know most of you are men - not sure if there are any female pain docs who could chime in? Sigh.
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
Dear Dr. Ducttape, Beginning in 2020, our Board will offer its longitudinal assessment technology to diplomates of other medical specialties to maintain their Pain Medicine certification. Until now, diplomates of our co-sponsoring boards – American Boards of Physical Medicine and Rehabilitation (ABPMR), Psychiatry and Neurology (ABPN), and Radiology (ABR) – with current certificates in Pain Medicine took a high-stakes recertification exam every 10 years. Our Pain Medicine-certified... New for Pain Recertification- re PMR
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
(Houston Methodist) Surgeons at Houston Methodist Hospital are stemming the tide of addiction to prescription opioids by managing patients' pain after surgery.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(Columbia University Irving Medical Center) A new study from researchers at Columbia University Vagelos College of Physicians and Surgeons found that non-medical cannabis use -- including frequent or problematic use -- is significantly more common in adults with pain than in those without pain.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
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