Autosomic dominant familial Beh çet disease and haploinsufficiency A20: A review of the literature

Discussion/conclusion High fever flares and digestive involvement starting in early childhood seem to be hallmarks of HA20 clinical features. Response to colchicine is unpredictable and biotherapies like anti-TNFα and anti IL1 appear to be treatments of choice, like for other auto-inflammatory diseases. Prospective description of larger cohort of HA20 cases is needed to understand better when this disease must be looked for and how to treat these patients.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research