The effect of a commercial competitive exclusion product on the selection of enrofloxacin resistance in commensal E. coli in broilers.

The effect of a commercial competitive exclusion product on the selection of enrofloxacin resistance in commensal E. coli in broilers. Avian Pathol. 2018 Jun 07;:1-28 Authors: Chantziaras I, Smet A, Filippitzi ME, Damiaans B, Haesebrouck F, Boyen F, Dewulf J Abstract The effect of a competitive exclusion product (Aviguard®) on the selection of fluoroquinolone resistance in poultry was assessed in vivo in the absence or presence of fluoroquinolone treatment. Two experiments using a controlled seeder-sentinel animal model (2seeders:4sentinels per group) with one-day-old chicks were used. For both experiments,as soon as the chicks were hatched, the animals of two groups were administered Aviguard® and two groups were left untreated. Three days later, all groups were inoculated with an enrofloxacin-susceptible commensal E. coli strain. Five days after hatching, two animals per group were inoculated either with a bacteriologically-fit or a bacteriologically non-fit enrofloxacin-resistant commensal E. coli strain. In experiment 2, all groups were orally treated for three consecutive days (Day 8-10) with enrofloxacin. Throughout the experiments, faecal excretion of all inoculated E. coli strains was determined on days 2-5-8-11-18-23 by selective plating (via spiral plater). Linear mixed models were used to assess the effect of Aviguard® on the selection of fluoroquinolone resistance. The use of Aviguard® (p<0.01) reduced the excretio...
Source: Avian Pathology - Category: Pathology Authors: Tags: Avian Pathol Source Type: research