Parkinson's: Vitamin B-3 may stop brain cell death

A Parkinson's study using human cells and a fly model found that a form of vitamin B-3 prevented the death of brain cells by preserving their mitochondria.
Source: Parkinson's Disease News From Medical News Today - Category: Neurology Tags: Parkinson's Disease Source Type: news

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Authors: Bor-Seng-Shu E, Paschoal FM, Almeida KJ, De Lima Oliveira M, Nogueira RC, Teixeira MJ, Walter U Abstract Substantia nigra (SN) hyperechogenicity has been proved to be a characteristic finding for idiopathic Parkinson's disease (PD), occurring in more than 90% of the patients. This echofeature is owed to increased amounts of iron in the SN region and reflects a functional impairment of the nigrostriatal dopaminergic system. In a prospective blinded study in which a group of patients with early mild signs and symptoms of unclear Parkinsonism were followed until a definite clinical diagnosis of PD, the hypere...
Source: Journal of Neurosurgical Sciences - Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research
Publication date: Available online 19 June 2019Source: Biochimica et Biophysica Acta (BBA) - Proteins and ProteomicsAuthor(s): Zhengjian Lv, Mohtadin Hashemi, Siddhartha Banerjee, Karen Zagorski, Jean-Christophe Rochet, Yuri L. LyubchenkoAbstractThe spontaneous self-assembly of α-synuclein (α-syn) into aggregates of different morphologies is associated with the development of Parkinson's disease. However, the mechanism behind the spontaneous assembly remains elusive. The current study shows a novel effect of phospholipid bilayers on the assembly of the α-syn aggregates. Using time-lapse atomic force micro...
Source: Biochimica et Biophysica Acta (BBA) Proteins and Proteomics - Category: Biochemistry Source Type: research
Authors: Chacko J, George S, Cyriac S, Chakrapani B Abstract Artistic creativity can emerge in patients with Parkinson's disease. Here we describe two patients who had creative awakening while on levodopa treatment for Parkinson's disease and discuss its implications. PMID: 31212166 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
AbstractDJ-1 is a protein with a wide range of functions importantly related to redox regulation in the cell. In humans, dysfunction of thePARK7 gene is associated with neurodegeneration and Parkinson ’s disease. Our objective was to establish a novel DJ-1 knockout zebrafish line and to identify early brain proteome changes, which could be linked to later pathology. The CRISPR-Cas9 method was used to target exon 1 of thepark7-/- gene to produce a transgenic DJ-1-deficient zebrafish model of Parkinson ’s disease. Label-free mass spectrometry was employed to identify altered protein expression in the DJ-1 null br...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
Extensive research in recent decades has expanded our insights into the pathogenesis of Parkinson’s disease (PD), though the underlying cause remains incompletely understood. Neuroinflammation have become a point of interest in the interconnecting areas of neurodegeneration and infectious diseases. The hypothesis concerning an infectious origin in PD stems from the observation of Parkinson-like symptoms in individuals infected with the influenza virus who then developed encephalitis lethargica. The implications of infectious pathogens have later been studied in neuronal pathways leading to the development of parkinso...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusions: We conclude, that exergaming, as an easy to apply, safe technique, can improve deficits in cognitive-motor dual-tasking and attention in PD.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
In this report, we present the case of a 65-year-old female with a 13-year history of akinetic-rigid idiopathic PD who developed recurrent episodes of “on” FoG after bilateral subthalamic nucleus deep brain stimulation (STN-DBS). She underwent STN-DBS for management of motor fluctuations, which resulted in a marked improvement in her motor symptoms. Within the next 6 months and after several programming sessions, the patient reported “on” FoG occurring regularly one hour after taking levodopa and lasting a few hours. Accordingly, a repeated levodopa challenge showed that FoG resolved with either l...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
ConclusionsD2R stimulation impairs reversal learning by blocking the impact of negative feedback.
Source: Psychopharmacology - Category: Psychiatry Source Type: research
Source: International Journal of Speech-Language Pathology - Category: Speech-Language Pathology Authors: Source Type: research
CONCLUSIONS: The varied pharmacologic mechanisms of NBP involve many complex molecular mechanisms; however, there many unknown pharmacologic effects await further study. PMID: 31205106 [PubMed - in process]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
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