Adherence to thyroid hormone replacement therapy: a retrospective, claims database analysis.

CONCLUSIONS: This large, retrospective real-world study demonstrated that adherence to levothyroxine remains a concern among patients with hypothyroidism and that differences in adherence may exist across levothyroxine formulations. PMID: 29874941 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research

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CONCLUSION: Higher all-cause mortality among those with excess iodine intake, compared with individuals with adequate iodine intake, highlights the importance of monitoring population iodine status. Further studies with longitudinal measures of iodine status are needed to validate our results and assess the potential risks excess iodine intake may have on long-term health outcomes. PMID: 29882490 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Conclusion: Screening breast cancer patients for thyroid function status at baseline and serially post-treatment to evaluate the need for thyroid hormone replacement may provide for a novel strategy for treating chemotherapy-induced fatigue. PMID: 29876020 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Valea A, Georgescu CE Abstract Selenium (Se) has a multilevel, complex and dynamic effect on the human body as a major component of selenocysteine, incorporated into selenoproteins, which include the selenocysteine-containing enzymes iodothyronine deiodinases. At the thyroid level, these proteins play an essential role in antioxidant protection and hormone metabolism. This is a narrative review based on PubMed/Medline database research regarding thyroid physiology and conditions with Se and Se-protein interferences. In humans, Se-dependent enzyme functions are best expressed through optimal Se intake, alth...
Source: Hormones - Category: Endocrinology Tags: Hormones (Athens) Source Type: research
Authors: Hepp Z, Lage MJ, Espaillat R, Gossain VV Abstract OBJECTIVE: To evaluate outcomes associated with adherence to levothyroxine (LT4) in the US adult hypothyroidism population. METHODS: We used data from Truven's MarketScan databases from July 1, 2011 through December 31, 2015. Patients aged 18 or older were diagnosed with hypothyroidism (confirmed at least twice) and prescribed LT4. Patients were excluded if they did not have continuous insurance coverage or if they received a diagnosis of thyroid cancer or pregnancy during the study period. Multivariable analyses on a matched cohort of adherent and non-...
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
In this study, we investigated the effect of RAI-induced hypothyroidism on the long bones during the pubertal growth spurt using immature female rats. Female Sprague-Dawley rats were randomly divided into a control group, and an RAI-treated group fed with RAI (0.37 MBq/g body weight) twice via gavage. After 4 weeks, we observed a significantly-reduced serum free thyroxine level in the RAI group. The latter group also displayed decreased body weight gain compared to the control. In addition, the lengths of long bones, such as the leg bones and vertebral column, as well as bone mineral content, were reduced in the RAI-treate...
Source: Experimental Animals - Category: Research Tags: Exp Anim Source Type: research
1681Background: In preparation for 131I ablation, temporary withdrawal of thyroid hormone is commonly used in patients with thyroid cancer after total thyroidectomy. Aim of this study was to characterize brain metabolic abnormalities in these patients,and the relation with mood dysfunction using 18F-fluoro-2-deoxyglucose positron emission tomography (18F-FDG-PET). METHOD: A total of 75 consecutive adult patients(mean age 47.8±10.5 y;women,39.7%) with thyroid carcinoma who had undergone total thyroidectomy were recruited for this cross-sectional study. All of them were hypothyroid after four weeks of thyroid hormone ...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry Imaging Posters Source Type: research
We report successful long term results of twice weekly administered intramuscular l-thyroxine therapy. We also draw attention to neurologic side effects of high dose l-thyroxine therapy. PMID: 29778126 [PubMed - in process]
Source: Journal of the National Medical Association - Category: General Medicine Tags: J Natl Med Assoc Source Type: research
Abstract While thyroid cancer risks from exposure to ionizing radiation early in life are well characterized quantitatively, the association of radiation with nonmalignant, functional thyroid disorders has been less studied. Here, we report on a risk analysis study of hypothyroidism with radiation dose to the thyroid gland and the hypothalamic-pituitary axis among survivors of childhood cancer. Utilizing data from the Childhood Cancer Survivor Study, a cohort of 14,364 five-year survivors of childhood cancer diagnosed at 26 hospitals in the U.S. and Canada between 1970 and 1986 and followed through 2009, the occur...
Source: Radiation Research - Category: Physics Authors: Tags: Radiat Res Source Type: research
ConclusionThis study demonstrated that thyroid gland is affected by radiotherapy significantly and the TSH increased after radiotherapy. Protecting thyroid gland during radiation and follow-up of patients with breast cancer RT are suggested for the assessment of thyroid gland dysfunction.
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
Hypothyroidism caused by tyrosine kinase inhibitors used in thyroid cancer treatment has been linked to longer survival rates, according to a study published inThyroid.Medscape
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
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