Major depression is more persistent in older people

Major depressive disorder in patients aged 70 or older is associated with a poorer prognosis than in younger people Related items fromOnMedica New evidence on benzodiazepine link to Alzheimer ’s Anxiety in midlife linked to risk of later dementia Suicide no more likely in men on 5 α-reductase inhibitors Antidepressants differ in effect on weight gain Doctors debate long-term use of psychiatric drugs
Source: OnMedica Latest News - Category: UK Health Source Type: news

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Abstract OBJECTIVE: Investigate Vitamin D3 (VD3) effect on the Acetylcholinesterase (AChE), oxidative damage and behavioral tests in animals subjected to Intracerebroventicular injection of Streptozotocin (ICV-STZ) simulating a Sporadic Dementia of Alzheimer's Type (SDAT) and treated with VD3 (21 days). METHODS: Animals were divided into eight groups: Vehicle, VD12.5 μg/kg, VD42 μg/kg, VD125 μg/kg, STZ, STZ+VD12.5 μg/kg, STZ+VD42 μg/kg, STZ+VD125 μg/kg. RESULTS: VD3 prevented the increase in AChE in groups of VD42 µg/kg and VD125 µg/kg; in AChE of synaptossom...
Source: Redox Report : communications in free radical research - Category: Biochemistry Authors: Tags: Redox Rep Source Type: research
We describe the fabrication of an amperometric and non-enzymatic biosensor based on WO3 NBs@GR nanocomposite modified electrode for nanomolar detection of PGT. The results showed that the nanocomposite modified electrode exhibit well-defined electro-oxidation peak compared to bare and control electrodes, demonstrating the superior electrocatalytic ability and performances. The fabricated modified sensor was facilitates the analysis of PGT in the concentration ranges of 0.025-1792.5 µM with a low detection limit of 4.28 nM. Further, the as-prepared WO3 NBs@GR electrode has been applied to determination of PGT in h...
Source: Ultrasonics Sonochemistry - Category: Chemistry Authors: Tags: Ultrason Sonochem Source Type: research
Authors: Lai AX, Kaup AR, Yaffe K, Byers AL Abstract OBJECTIVE: To compare occurrence of clinically diagnosed psychiatric disorders and suicidal behavior (mental health disorders) across dementia subtypes in the largest healthcare system in the United States. METHODS: We aggregated two national databases (Department of Veterans Affairs [VA] National Patient Care Database, National Suicide Prevention Applications Network [SPAN]) and estimated 2-year prevalence of mental health disorders across five dementia subtypes during fiscal years 2012-2013. Using VA healthcare systems throughout the United States, the samp...
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
Something’s just not right: lately you are forgetful, stressed, and tired all of the time. Symptoms can vary from mood swings, to lack of concentration, to feeling chronically tired, and anxious. To top it off, no matter how healthy you try to eat, you still aren’t losing weight. So let’s add frustrated to the list. And you’re finding that all of this is affecting your performance at work, as a parent, and even as a partner/spouse. It’s not your imagination.  Grains are behind it all… The grains you consume may have numerous damaging effects on your brain and nervous system, not ju...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates adhd anxiety appetite control blood sugar brain brain fog Brain function dementia Dr. Davis grain grains Inflammation learning ability libido mood mood swings psychiatric disorders seizures Source Type: blogs
Imagine a world in which caring for the deeply forgetful is deemed a privilege and a trust.By Stephen PostAlzheimer's Reading RoomI do believe that we will see a spiritual-cultural shift away from the ideology of “hyper-cognitive values” that has regrettably blinded us to the enduring selves underlying the deeply forgetful.How can we encounter the deeply forgetful outside of hyper-cognitive ideologies?Dementia Patients are People TooHow can we bear witness to the reality that persons with this cognitive disability possess inherent qualities, and create a culture where all are welcomed and celebrated regardless ...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alz alzheimers bond cruelty deeply forgetful dehumanizing others demenitia glass half full love privilege self identity Spiritual Cultural Evolution Stephen Post trust Source Type: blogs
Conclusion: This novel technology discriminates and quantifies subtle differences in behavior and neurological impairments in subjects afflicted with neurological injury/disease. KINARM assessments can be incorporated into multi-center trials (e.g., monitoring stroke motor recovery: NCT02928393). Further studies will determine if KINARM Labs can demonstrate a clinical effect with fewer subjects over a shorter trial period. Disclosures/funding: Dr. Stephen Scott is the inventor of KINARM and CSO of BKIN Technologies.   Multiplexed mass spectrometry assay identifies neurodegeneration biomarkers in CSF Presenter: Chelsky...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Assessment Tools biomarkers Cognition Current Issue Drug Development General Genetics Medical Issues Neurology Patient Assessment Psychopharmacology Scales Special Issues Supplements Trial Methodology clinical trials CNS Su Source Type: research
CONCLUSIONS: Childhood stress appears to have a significant impact on emotional health and dementia for older Aboriginal Australians. The ongoing effects of childhood stress need to be recognized as people grow older, particularly in terms of dementia prevention and care, as well as in populations with greater exposure to childhood adversity, such as Aboriginal Australians. PMID: 28689644 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
This study examined the validity of the Childhood Trauma Questionnaire (CTQ) in a community sample of older Aboriginal Australians• The CTQ was acceptable in this population and associated with other adverse childhood indicators, such as removal from family in childhood• Higher levels of childhood stress and adversity were associated with late-life emotional health (depression, anxiety/PTSD, suicide attempt), dementia and Alzheimer's disease• These results contribu te to a growing body of research suggesting adverse early life exposures increase dementia risk in older age.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Regular Research Articles Source Type: research
This article provides an important and easilyunderstandable introduction to grief—the types, states and symptoms Alzheimer’s caregivers will most likely have to face.Caregiver Excellence and Alzheimer's CareSubscribe to the Alzheimer's Reading RoomEmail:Types of Grief1.Mourning the Loss of the “Person Who Was.” This is a type of grief particularly strong for caregivers of people who are living with Alzheimer ’s. It is prompted by the loved one’s personality changes and deterioration of cognitive ability.Caregivers can fall into a deep state of despair as their loved one declines.Coping w...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer's care caring for dementia patients at home dementia care dementia help for caregivers family caregiving grief health help alzheimer's help with dementia care Source Type: blogs
Susan Schneider Williams, Robin Williams’ widow, wrote a devastating account of her husband’s final year of life before he died by suicide in 2014. An autopsy revealed that Robin Williams had Lewy body disease, an umbrella term used to describe both Parkinson’s disease dementia and dementia with Lewy bodies. In a letter this week addressed to neurologists, Susan described the “terrorist” who lived inside her husband’s brain and caused him to forget his movie lines, plagued him with delusions and paranoia, and engulfed him in fear, anxiety and depression. Her account of his medi...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
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