Preeclampsia Risks in Kidney Donors and Recipients
AbstractPurpose of ReviewTo review the studies and practice guidelines on the preeclampsia risks in kidney donors and recipients.Recent FindingsThere is a small increased risk of gestational hypertension and preeclampsia in pregnancies that follow kidney donation. Kidney Disease Improving Global Outcomes (KDIGO) Clinical Practice Guideline (2017) and the 2015 American Society of Transplantation (AST) consensus conference statement recommends counseling kidney donors about this increased risk. There is no observed increase in fetal complications or eclampsia post-kidney donation. Preeclampsia is more commonly observed in kidney transplant recipients than the general population and these patients should be co-managed with an obstetrician with experience in managing high risk pregnancies. Although preeclampsia has not been found to have a deleterious effect on renal graft function, it can cause premature delivery. Risk calculators have been proposed and an elevated pre-pregnancy creatinine seems to be an important risk. KDIGO Clinical Practice Guidelines (2009) recommends attempting pregnancy when kidney function is stable with proteinuria of less than 1 g per day. The use of novel biomarkers for preeclampsia has not been published in this population.SummaryPreeclampsia is an important concern for female kidney donors and recipients of child-bearing age. These individuals should be appropriately counseled.
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ConclusionsThis is the first randomised investigation of BP self-monitoring for the management of pregnancy hypertension and indicates that a large RCT would be feasible.
Publication date: Available online 12 October 2019Source: Journal of Hospital InfectionAuthor(s): Jaspreet Dhanda, James Gray, Ellen Knox, Amreen Bashir
In the original publication of this article , there are error in the Fig. 5, the “ml” should be replaced by “mL” (Fig. 5A) and “IFNγ” should be “IFN-γ” in Fig. 5A, B. The correct figure is below:
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Authors: Bhullar SK, Shah AK, Dhalla NS Abstract Effective therapy of hypertension represents a key strategy for reducing the burden of cardiovascular disease and its associated mortality. The significance of voltage dependent L-type Ca²⁺ channels to Ca²⁺ influx, and of their regulatory mechanisms in the development of heart disease, is well established. A wide variety of L-type Ca²⁺ channel inhibitors and Ca²⁺ antagonists have been found to be beneficial not only in the treatment of hypertension, but also in myocardial infarction and heart failure. Over the past two decades, another cla...
Publication date: Available online 12 October 2019Source: PeptidesAuthor(s): Bingjun Qian, Chongchong Tian, Jianghua Huo, Zhiwen Ding, Ran Xu, Juan Zhu, Lili Yu, Oscar D. VillarrealAbstractThe current study investigated the angiotensin-converting enzyme (ACE) inhibitory activity of 4 synthetic tripeptides. All the peptides showed enzyme inhibitory activity, especially two promising ones, TTP (Thea-Thea-Pro) and gAgAP (GABA-GABA-Pro), with IC50 values of 0.92 and 3.4μmol/L, respectively. Enzyme inhibition kinetics determined by Lineweaver-Burk plots revealed that TTP and gAgAP were competitive inhibitors with Ki value...
Emerging science indicates that fathers play a more significant role in pregnancy outcomes than previously thought.