Mass. Researchers May Be On Brink Of Creating Revolutionary, Non-Addictive Painkiller

CAMBRIDGE (CBS NEWS) — Researchers in Massachusetts believe they may be on the brink of creating a revolutionary non-addictive painkiller. Developed by Blue Therapeutics, Blue-181 could be a big step forward in dealing with the growing opioid crisis. The team there said it wanted to make a drug that is a total replacement for the opioids currently on the market – something that people could safely stop using without the possible dangerous side effects. Mark Loccisano felt a gratification from painkillers with his very first pill. They were prescribed by a doctor for a sports injury. It was the beginning of an opioid addiction that consumed his 20s and nearly cost him his life, reports CBS News’ Kenneth Craig. “Not many people know they’re addicts until they start using,” Loccisano said. “I ended up wrapping my work truck around a telephone pole one night, on my way home from work….And that wasn’t even enough for me to stay clean.” Loccisano is now in treatment at St. Christopher’s Inn, which is run by a ministry of the Franciscan Friars of the Atonement in Garrison, New York. He’s part of a staggering number of Americans swept up in the nation’s opioid epidemic. But now, three Harvard-trained scientists believe they’ve developed a breakthrough: a non-narcotic, non-addictive painkiller 50 times more powerful than morphine. “We were told the same thing about the painkillers currently on t...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Cambridge Local TV opioid crisis Source Type: news

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Breast cancer is the leading diagnosed cancer for women globally. Evolution of breast cancer in tumorigenesis, metastasis and treatment resistance appears to be driven by the aberrant gene expression and protein degradation encoded by the cancer genomes. The uncontrolled cancer growth relies on these cellular events, thus constituting the cancerous programs and rendering the addiction towards them. These programs are likely the potential anticancer biomarkers for Personalized Medicine of breast cancer. This review intends to delineate the impact of the CRSPR/Cas-mediated genome editing in identification and validation of t...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Background: Esophageal stent insertion in patients with inoperable esophageal cancer is usually accompanied with relatively high adverse symptoms and even mortality. The current study aims at investigating the outcomes of esophageal stenting in patients with inoperable non-cervical esophageal cancer.Materials and Methods: The current descriptive-analytical research evaluates 25 patients with esophageal cancer. The stent was placed in esophagus based upon endoscopy analysis with or without fluoroscopy and then the stent position and its opening was investigated by making use of CXRand Gastrografin studies. Demographic chara...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Background: Due to the severity of the primary disease in patients with lung cancer, quality of life (QoL) is often overlooked. Factors that form QoL should be taken in consideration when planning the appropriate treatment and determining therapy targets, because of the increasing frequency of bone metastasis leading to high levels of pain. Purpose of this study is to assess quality of life in patients with lung cancer, before and after treatment combined with zoledronic acid.Methods and materials: QoL was assessed in 80 patients (49 males-31 females), of which 45 developed bone metastasis. Prior and post treatment (with c...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Conclusions: The cells rely more on glucose/gltamine have a stronger sensitivity to glucose/glutamine depletion or glycolysis/ glutaminolysis inhibition and a lessened sensitivity to glutaminolysis/glycolysis inhibitors. To target tumor metabolism based on metabolic characteristics may provide a new therapeutic strategy for the treatment of B cell lymphoma.
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
Background: The Zusanli (ST36) acupoint has been associated with treatment of various gastrointestinal conditions. There have been no studies of acupuncture therapy for paralytic postoperative ileus (PPOI).Materials and methods: Patients with PPOI following gastrectomy for gastric cancer were randomized to receive ST36 acupoint injection with neostigmine, gluteal intramuscular injection with 1.0 mg neostigmine, ST36 acupuncture alone, or standard therapy. The main outcome was the effectiveness rate for recovery of peristalsis. Secondary outcomes were time to bowel sound recovery, time to first flatus, and time to first def...
Source: Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Research Paper Source Type: research
ARTHRITIS pain could be treated by making changes to your diet and exercise plans. You could prevent joint symptoms by eating more of this cheap fruit, it ’s been claimed.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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Source: Topics in Pain Management - Category: Anesthesiology Tags: Continuing Education Activity Source Type: research
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Source: Topics in Pain Management - Category: Anesthesiology Tags: Article Source Type: research
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Source: Topics in Pain Management - Category: Anesthesiology Tags: CE Quiz Source Type: research
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Source: Topics in Pain Management - Category: Anesthesiology Tags: News in Brief Source Type: research
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