A Metabolite-Triggered Tuft Cell-ILC2 Circuit Drives Small Intestinal Remodeling

We describe a metabolic sensing circuit that may have evolved to facilitate mutualistic responses to luminal pathosymbionts. Graphical abstract Teaser Succinate produced by mutualistic colonizing protozoa activates a small intestinal tuft cell-ILC2 circuit, leading to adaptive remodeling that facilitates energy homeostasis and infection resistance in the host and a reproductive niche for the pathosymbiont.
Source: Cell - Category: Cytology Source Type: research