Usefulness of cancer-free survival in estimating the lifetime attributable risk of cancer incidence from radiation exposure

Risk projection models estimating the lifetime cancer risk from radiation exposure are generally
based on exposure dose, age at exposure, attained age, gender and study-population-specific factors
such as baseline cancer risks and survival rates. Because such models have mostly been based on the
Life Span Study cohort of Japanese atomic bomb survivors, the baseline risks and survival rates in
the target population should be considered when applying the cancer risk. The survival function used
in the risk projection models that are commonly used in the radiological protection field to
estimate the cancer risk from medical or occupational exposure is based on all-cause mortality.
Thus, it may not be accurate for estimating the lifetime risk of high-incidence but not
life-threatening cancer with a long-term survival rate. Herein, we present the lifetime attributable
risk (LAR) estimates of all solid cancers except thyroid cancer, thyroid cancer, and leukemia except
chronic lymphocyt...

Source: Journal of Radiological Protection - June 6, 2018 Category: Physics Authors: Songwon Seo, Dal Nim Lee, Young Woo Jin, Won Jin Lee and Sunhoo Park Source Type: research