Peripheral hemophagocytosis: A rapid clue to severe sepsis and hemophagocytic lymphohistiocytosis

A 42-day-old girl, born at 36 weeks of gestation with a birth weight of 2.1  kg, was referred to our hospital from a neighboring country with complaints of 10 days of persistent fever, anemia, and severe thrombocytopenia. Initial physical examination findings revealed jaundice and significant hepatosplenomegaly. Vital signs were stable, and no oxygen was required. Complete blood count, after recent red cell and platelet transfusions, revealed hemoglobin 9.0 g/dL, WBC 22.57 × 109/L, and platelet 11 × 109/L.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Images Source Type: research

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Abstract Malaria is a parasitic infection of global importance but has a high prevalence in the developing countries. Renal failure is a common complication of severe Plasmodium falciparum malaria and has been reported in up to 40% of all cases. Acute kidney injury (AKI), however, is not commonly associated with Plasmodium vivax infection. In those patients who develop AKI following P. vivax infection, the cause is commonly attributed to mixed undiagnosed falciparum infection or coexistent sepsis, dehydration, or hypotension. Infrequently, an association of P. vivax infection with thrombotic microangiopathy (TMA) ...
Source: Saudi Journal of Kidney Diseases and Transplantation - Category: Urology & Nephrology Authors: Tags: Saudi J Kidney Dis Transpl Source Type: research
Conclusion and Future Directions The ECM model has produced a wealth of information on CM pathogenesis in mice with the aim to find an adjunctive therapy for HCM but its validity has been questioned. However, several investigators have provided a critical and evidence-based defense of this model (17, 128–131) and from knowledge gained from it, numerous laboratories have tested preclinical therapeutic interventions. Many have demonstrated efficacy at blocking the development of ECM but disappointingly, in a majority of cases, this was only found when administered before or early post infection and prior to the onset ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 22 February 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Bruna Copat, Paulo Vinicius Bastiani, Fernanda Catelari Jaconi, Wanderley Wallyson Damarem, André Felipe Streck, Eduardo Conceição de Oliveira, Luciana Sonne, Raqueli Teresinha FrançaAbstractRangeliosis, caused by protozoan Rangelia vitalii, is transmitted by the tick Amblyomma aureolatum. The disease is characterized by hemolytic and hemorrhagic disorder and has been described in dogs and other wild canids. The aim of this study was to compare clinicopathological findings and laboratory results of...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
ConclusionHLH is a devastating disease that potentially culminates in multisystem organ failure if not appropriately treated. At the time of clinical suspicion of HLH, approximately 3 days after the patient's admission, his clinical condition had improved on high dose steroids alone, therefore additional immunosuppression was not initiated. The patient might have had EBV that precipitated his HLH, however at the time of diagnosis his viral load was less than 2000 copies/mL and antiviral therapy was not considered necessary. He continues to be in remission, asymptomatic, 9 months after original diagnosis.Figure.DisclosuresN...
Source: Blood - Category: Hematology Authors: Tags: 203. Lymphocytes, Lymphocyte Activation, and Immunodeficiency, including HIV and Other Infections Source Type: research
A 27 year old male with no significant past medical history presented to an outside hospital for chief complaints of nausea/vomiting, epigastric pain, and acute jaundice. Initial laboratory workup revealed a hemoglobin of 5.5 g/dl, normal WBC and platelet count, elevated direct bilirubin (10 mg/dl), elevated lactate dehydrogenase (969 IU/L), low haptoglobin (
Source: Blood - Category: Hematology Authors: Tags: 401. Basic Science and Clinical Practice in Blood Transfusion Source Type: research
Conclusion: P. vivax is an important cause of severe malaria with AKI in our setting. Various other clinical features are associated with AKI and related mortality.
Source: Indian Journal of Critical Care Medicine - Category: Intensive Care Authors: Source Type: research
Publication date: Available online 11 September 2018Source: Ticks and Tick-borne DiseasesAuthor(s): Adi W. Naor, Dana M. Lindemann, Megan E. Schreeg, Henry S. Marr, Adam J. Birkenheuer, James W. Carpenter, Julia K. RyseffAbstractA possible novel Babesia species infection of a maned wolf (Chrysocyon brachyurus) was first reported in 2012. The current case details a confirmed report of a maned wolf with infection by an undetermined species of Babesia. As the mortality and morbidity of babesiosis is high, this may become a significant concern to captive maned wolves, which are considered a near-threatened species by the World...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Conclusion: Thrombocytopenia and hepatic dysfunction were more common in dengue, while anaemia, splenomegaly, jaundice and convulsions were more frequent in falciparum malaria. Neurological sequelae and cases of acute renal failure were almost equal in both the infections. PMID: 30123804 [PubMed]
Source: Iranian Journal of Arthropod-Borne Diseases - Category: Infectious Diseases Tags: J Arthropod Borne Dis Source Type: research
Source: Blood - Category: Hematology Authors: Tags: Pediatric Hematology, Free Research Articles, BloodWork, Platelets and Thrombopoiesis, Thrombosis and Hemostasis BLOOD WORK Source Type: research
Authors: Yinon Y, Farine D, Yudin MH Abstract OBJECTIVES: To review the principles of prenatal diagnosis of congenital cytomegalovirus (CMV) infection and to describe the outcomes of the affected pregnancies. OUTCOMES: Effective management of fetal infection following primary and secondary maternal CMV infection during pregnancy. Neonatal signs include intrauterine growth restriction (IUGR), microcephaly, hepatosplenomegaly, petechiae, jaundice, chorioretinitis, thrombocytopenia and anemia, and long-term sequelae consist of sensorineural hearing loss, mental retardation, delay of psychomotor development, and vi...
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
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