Men may contribute to infertility through newly discovered part of sperm

(University of Toledo) The research identifies a new structure in human sperm that functions in the zygote and may provide new avenues for addressing male infertility and insights into early embryo developmental defects.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news

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Most patients going through IVF treatment are fed up of hearing the advice that they should just relax and not get stressed out.Everyone knows that stress is not good for you , and no one chooses to be stressed, but telling people to relax is hardly helpful. After all, how do you implement advice like that? Stress is a completely normal human psychological response – especially when you are going through an expensive  treatment like IVF, where the outcome is so uncertain.I'm a strong believer in the fact that it's not stress which affects fertility - it's the infertility which causes stress . I ’m sure if ...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
Many infertile patients get major heartburn when they realize that they aren't able to afford test tube baby treatments because they are so expensive. They can't understand why IVF doctors charge so much, and lots of patients end up thinking of IVF clinics as being greedy.Patients need to understand that part of test tube baby treatment is clinical – and this is what the patient sees. This includes: consultations, blood tests, ultrasound scans, egg collection, and embryo transfer.However, the heart of the IVF treatment is the IVF laboratory, and the patient doesn ’t get to see what goes on behind the scenes in ...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
Conclusion:Taken together, murine uterine damage models were most successfully established by chemical treatment. This production protocols could be applied further to larger animals such as non-human primate.
Source: Tissue Engineering and Regenerative Medicine - Category: Biotechnology Source Type: research
As SCs play a central role in germ cesurvival, their death may results in marked germ cell loss and infertility (Eid et al., 2012; Oliveira et al., 2015). As SCs play a central role in germ cell survival, their death may result in marked germ cell loss and infertility (Eid et al., 2012; Oliveira et al., 2015). As SCs play a central role in germ cell survival, their death may result in marked germ cell loss and infertility (Eid et al., 2012; Oliveira et al., 2015). Sertoli cells (SCs) are the only somatic cells within the seminiferous tubules and are essential for regulating spermatogenesis.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Regular Article Source Type: research
NLRP3 is part of the NLRP3 inflammasome and a global sensor of cellular damage. It was recently discovered in rodent Sertoli cells. We investigated NLRP3 in mouse, human and non-human primate (marmoset and rhesus macaque) testes, employing immunohistochemistry. Sertoli cells of all species expressed NLRP3, and the expression preceded puberty. In addition, peritubular cells of the adult human testes expressed NLRP3. NLRP3 and associated genes (PYCARD, CASP1, IL1B) were also found in isolated human testicular peritubular cells and the mouse Sertoli cell line TM4. Male infertility due to impairments of spermatogenesis may be ...
Source: Reproduction - Category: Reproduction Medicine Authors: Tags: Research Source Type: research
In conclusion, in this study, we demonstrated for the first time a novel target for FXR and that the activated receptor alters the acquisition of sperm fertilising ability. We showed that sperm itself express the FXR and it is responsive to specific ligands of the receptor; therefore, bile acids influence this cell both in male and in female genital tracts. It might be hypothesized that bile acid levels could be involved in infertility with idiopathic origin as these compounds are not systematically measured in men undergoing medically assisted procreation.
Source: Reproduction - Category: Reproduction Medicine Authors: Tags: Research Source Type: research
ConclusionThe results indicated a significant correlation between mutations in exon 19 (rs121913438) and exon 21(rs121434568) of EGFR gene and susceptibility of myoma in the study population.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
(American Society for Biochemistry and Molecular Biology) Proteomic analysis of oocytes from obese mice showed changes in a protein that promotes antioxidant production and may alter meiotic spindles.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Multiple morphological abnormalities of the sperm flagellum (MMAF) is a severe form of male infertility defined by the presence of a mosaic of anomalies, including short, bent, curled, thick, or absent flagella, resulting from a severe disorganization of the axoneme and of the peri-axonemal structures. Mutations in DNAH1, CFAP43, and CFAP44, three genes encoding axoneme-related proteins, have been described to account for approximately 30% of the MMAF cases reported so far. Here, we searched for pathological copy-number variants in whole-exome sequencing data from a cohort of 78 MMAF-affected subjects to identify additiona...
Source: The American Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
Flagella and motile cilia share a 9  + 2 microtubule-doublet axoneme structure, and asthenozoospermia (reduced spermatozoa motility) is found in 76% of men with primary ciliary dyskinesia (PCD). Nevertheless, causal genetic variants in a conserved axonemal component have been found in cases of isolated asthenozoospermia: 30% of men w ith multiple morphological anomalies of sperm flagella (MMAF) carry bi-allelic mutations in DNAH1, encoding one of the seven inner-arm dynein heavy chains of the 9 + 2 axoneme.
Source: The American Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Tags: Report Source Type: research
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