Funding opportunity announcement from The National Institute for Occupational Safety and Health (NIOSH).

Funding opportunity announcement from The National Institute for Occupational Safety and Health (NIOSH).Link: Funding OpportunityContent-type: links
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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We examined the relationship between the metabolic processes of carbon catabolite repression (CCR), nitrogen catabolite repression (NCR) and virulence in a variety of A. fumigatus clinical isolates. A considerable amount of heterogeneity with respect to the degree of CCR and NCR was observed and a positive correlation between NCR and virulence in a neutropenic mouse model of pulmonary aspergillosis (PA) was found. Isolate Afs35 was selected for further analysis and compared to the reference strain A1163, with both strains presenting the same degree of virulence in a neutropenic mouse model of PA. Afs35 metabolome analysis ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion and Perspectives CYP51 plays a crucial role in fungal invasive growth, hyphae formation and virulence, and inhibitors targeting CYP51 have always been an important component of antifungal agents. Further researches on fungal CYP51s might set about from the following aspects: First, while the detailed crystal structures of several susceptible pathogenic fungi CYP51 have been elaborated, those of drug-resistant variants are still in hypothesis. If those structures were elucidated, targeting at common drug-resistant CYP51 protein variants could probably be promising. Second, it deserves more in-depth researches to...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
This study has revealed the intestinal and hepatopancreas mycobiota of L. vannamei and the effects of diseases and seasonal variation to the mycobiota. Our study provides important guidance for Pacific white shrimp farming and sheds further insight on the fungal microbiota. Introduction The digestive system hosts a large number of microorganisms dominated by bacteria, which constitute an enormous microbial ecosystem called the microbiota (O’Hara and Shanahan, 2006; Clemente et al., 2012). The microbiota has multiple functions, such as the maintenance of the functional stability and metabolic balance in the di...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Date: Tuesday, April 23, 2019Year: 2019Location: Schloss Montabaur, GermanyContent-type: current_conferences
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Date: Tuesday, April 23, 2019Year: 2019Location: Students' Union Building atrium, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL UKContent-type: current_conferences
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Journal of Natural ProductsDOI: 10.1021/acs.jnatprod.8b00744
Source: Journal of Natural Products - Category: Biochemistry Authors: Source Type: research
Source: Chemistry of Natural Compounds - Category: Chemistry Source Type: research
Publication date: Available online 21 April 2019Source: Biotechnology ReportsAuthor(s): Igor A de Souza, Daniela C Orsi, Anderson J Gomes, Claure N LunardiAbstractThe use of alginate and chitosan polymer in the immobilization of Aspergillus oryzae ATCC 3940 fungal crude enzyme extract (CEE) amylase was presented. The assembly results change in the application of optimal pH and temperature hydrolysis to convert starch to sugar. Bead arrangement in three microgel supports: the internal support phase (IP), the external support phase (EP), and the internal and external support phase (UP). The best results were obtained using I...
Source: Biotechnology Reports - Category: Biotechnology Source Type: research
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Source: Mycology - Category: Biology Authors: Source Type: research
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