Effect of Sirtuin-1 on Synaptic Plasticity in Nucleus Accumbens in a Rat Model of Heroin Addiction.

CONCLUSIONS SIRT1 and other synaptic plasticity-related genes in NAc are involved in the regulation of heroin addiction. SIRT1 overexpression can increase behavioral sensitization in the NAc of rats, and SIRT1 silencing might ease withdrawal symptoms and reduce conditioned place preferences. PMID: 29870523 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/29870523?dopt=Abstract

Source: Medical Science Monitor - June 7, 2018 Category: Research Tags: Med Sci Monit Source Type: research