What's new in systemic sarcoma treatments?

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Source: Current Opinion in Oncology - Category: Cancer & Oncology Tags: SARCOMAS: Edited by Jean-Yves Blay Source Type: research

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Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Shohei Matsuo, Emiko Tomita, Kenjiro Fukuhara, Akinori Akashi, Yoshitane TsukamotoAbstractWe experienced two cases of poorly differentiated synovial sarcoma (PDSS) arising from the chest wall. The first 42-year-old female patient was asymptomatic, but incidental chest roentgenogram showed a chest wall mass about 5-cm in maximal diameter with extrapleural sign. The chest wall mass was removed at other hospital. A tentative pathological diagnosis was mesothelioma with small cell features. After several courses of chemotherapy consisting...
Source: Human Pathology: Case Reports - Category: Pathology Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
ConclusionsOn average, regression of ES seems to be worse in the extraosseous tumor compartment following preoperative chemotherapy. Moreover, extraosseous tumor regression may have a stronger prognostic influence on event-free survival than intraosseous regression.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Condition:   Kaposi Sarcoma Intervention:   Drug: Talimogene laherparepvec Sponsor:   Assistance Publique - Hôpitaux de Paris Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Mahmood Dhahir Al-MendalawiIndian Journal of Ophthalmology 2019 67(9):1507-1507
Source: Indian Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
Abstract: Synovial sarcoma (SS) is a high-grade soft-tissue sarcoma occurring predominantly in older children and young adults. Only approximately 7% occur in the head and neck region, with SS representing less than 0.1% of all head and neck cancers. Orbital location is exceedingly rare with only 8 cases reported so far in the literature. It is noted for its propensity for late local recurrences and metastases. Histologically, SS is monophasic, biphasic, or poorly differentiated and harbors a specific chromosomal translocation t(X;18)(p11.2;q11.2) in>95% of cases. In this article, we describe a case of monophasic SS p...
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Brief Report Source Type: research
Kaposi sarcoma (KS) is estimated to occur 500 times more frequently in organ transplant recipients (OTRs) than in the background population. Our academic teaching hospital has offered a dedicated OTR skin surveillance clinic since 1989, and we observed 16 cases of KS between 1989-2016. Eleven of these cases occurred in patients of black African/Caribbean (BAC) descent (8.4% of the overall BAC cohort (131 patients)). KS was significantly more common in OTRs of BAC descent than in patients of other ethnicities (P
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Dermatofibroma protuberans (DFSP) is an uncommon, locally aggressive cutaneous soft tissue sarcoma of low-intermediate malignancy that favors young adults. It usually presents as an asymptomatic, indurated, skin-colored plaque that enlarges over a period of months to years. Histologically, it is characterized by its capacity to infiltrate the dermis and subcutaneous tissue in the form of peripheral tentacle-like projections. This feature justifies a high rate of local recurrence, while the rate of metastasis remains low.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
Kaposi sarcoma (KS) is an angioproliferative neoplasm that is associated with human herpesvirus 8. Commonly appearing as a cutaneous manifestation, this condition also frequently involves multiple visceral organs including the respiratory and gastrointestinal tract. Therefore, despite being known as a low-grade tumor, this disease can manifest devastatingly depending upon its various sites of involvement. A 28-year-old homosexual male was admitted for 2 days of hemoptysis, minor bleed from right eye, and progressive facial rash.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
We present three unusual cases of healthy HIV-negative men who have sex with men (MSM) who developed asymptomatic cutaneous lesions on the lower extremities.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
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