What's new in systemic sarcoma treatments?
No abstract available
Publication date: November 2019Source: Human Pathology: Case Reports, Volume 18Author(s): Shohei Matsuo, Emiko Tomita, Kenjiro Fukuhara, Akinori Akashi, Yoshitane TsukamotoAbstractWe experienced two cases of poorly differentiated synovial sarcoma (PDSS) arising from the chest wall. The first 42-year-old female patient was asymptomatic, but incidental chest roentgenogram showed a chest wall mass about 5-cm in maximal diameter with extrapleural sign. The chest wall mass was removed at other hospital. A tentative pathological diagnosis was mesothelioma with small cell features. After several courses of chemotherapy consisting...
ConclusionsOn average, regression of ES seems to be worse in the extraosseous tumor compartment following preoperative chemotherapy. Moreover, extraosseous tumor regression may have a stronger prognostic influence on event-free survival than intraosseous regression.
Condition: Kaposi Sarcoma Intervention: Drug: Talimogene laherparepvec Sponsor: Assistance Publique - Hôpitaux de Paris Not yet recruiting
Mahmood Dhahir Al-MendalawiIndian Journal of Ophthalmology 2019 67(9):1507-1507
Abstract: Synovial sarcoma (SS) is a high-grade soft-tissue sarcoma occurring predominantly in older children and young adults. Only approximately 7% occur in the head and neck region, with SS representing less than 0.1% of all head and neck cancers. Orbital location is exceedingly rare with only 8 cases reported so far in the literature. It is noted for its propensity for late local recurrences and metastases. Histologically, SS is monophasic, biphasic, or poorly differentiated and harbors a specific chromosomal translocation t(X;18)(p11.2;q11.2) in>95% of cases. In this article, we describe a case of monophasic SS p...
Kaposi sarcoma (KS) is estimated to occur 500 times more frequently in organ transplant recipients (OTRs) than in the background population. Our academic teaching hospital has offered a dedicated OTR skin surveillance clinic since 1989, and we observed 16 cases of KS between 1989-2016. Eleven of these cases occurred in patients of black African/Caribbean (BAC) descent (8.4% of the overall BAC cohort (131 patients)). KS was significantly more common in OTRs of BAC descent than in patients of other ethnicities (P
Dermatofibroma protuberans (DFSP) is an uncommon, locally aggressive cutaneous soft tissue sarcoma of low-intermediate malignancy that favors young adults. It usually presents as an asymptomatic, indurated, skin-colored plaque that enlarges over a period of months to years. Histologically, it is characterized by its capacity to infiltrate the dermis and subcutaneous tissue in the form of peripheral tentacle-like projections. This feature justifies a high rate of local recurrence, while the rate of metastasis remains low.
Kaposi sarcoma (KS) is an angioproliferative neoplasm that is associated with human herpesvirus 8. Commonly appearing as a cutaneous manifestation, this condition also frequently involves multiple visceral organs including the respiratory and gastrointestinal tract. Therefore, despite being known as a low-grade tumor, this disease can manifest devastatingly depending upon its various sites of involvement. A 28-year-old homosexual male was admitted for 2 days of hemoptysis, minor bleed from right eye, and progressive facial rash.
We present three unusual cases of healthy HIV-negative men who have sex with men (MSM) who developed asymptomatic cutaneous lesions on the lower extremities.