Micropapillary urothelial carcinoma: evaluation of HER2 status and immunohistochemical characterization of the molecular subtype

In this study, we focused on micropapillary urothelial carcinoma (MPUC), an aggressive, histomorphologically defined rare variant. Apart from genetic alterations shared with conventional UBC alterations of the HER2 gene have been reported in higher frequencies. However, only small cohorts of MPUCs have been analyzed and the real impact is still unclear. We collected a cohort of 94 MPUCs and immunohistochemically tested HER2, basal (CD44, CK5, EGFR, p63) and luminal (CD24, FOXA1, GATA3, CK20) markers to allocate MPUC to a molecular subtype.

Source: Human Pathology - June 6, 2018 Category: Pathology Authors: Ulrike Zinnall, Veronika Weyerer, Eva Comp érat, Philippe Camparo, Nadine T. Gaisa, Ruth Knuechel-Clarke, Aurel Perren, Alessandro Lugli, Marieta Toma, Gustavo Baretton, Glen Kristiansen, Ralf M. Wirtz, Liang Cheng, Bernd Wullich, Robert Stoehr, Arndt Ha Tags: Original contribution Source Type: research