TP53 mutations in peripheral mature T and NK cell lymphomas: a whole-exome sequencing study with correlation to p53 expression

In this study, fifty-seven formalin-fixed paraffin-embedded samples were collected for whole-exome sequencing and immunohistochemical study. Ten cases had TP53 mutation variant allele frequency (VAF) of more than 5%, predominantly in intestinal T-cell lymphoma (60%), peripheral T-cell lymphoma, not otherwise specified (22.2%), and extranodal nasal-type NK/T-cell lymphoma (21.7%).

Source: Human Pathology - June 6, 2018 Category: Pathology Authors: Hui-Shan Huang, Chun-Kai Liao, Ting-Ting Liu, Huey-Ling You, Ming-Chung Wang, Wan-Ting Huang Tags: Original Contributions Source Type: research