Turning Surgeons Into Innovators Without Taking Them Out of the OR

Academic hospitals have all the makings for rich medical device development. They have physicians to identify surgical needs, researchers to test theories, bioengineers to design and create devices and patients to participate in clinical trials. However, disconnect between engineering and surgical departments makes innovation a challenge. So does surgeons' all-consuming job Number One—treating patients. Surgical Innovations, part of the University of California, San Francisco's Department of Surgery and Bioengineering &Therapeutic Sciences, aims to open communication between clinical academic surgeons and bioengineering colleagues. It also gives surgeons a platform to develop life-enhancing and lifesaving medical devices. Launched in 2015, Surgical Innovations draws on the expertise of one of the country's top medical schools for research and primary care. UCSF providers conduct more than 1,300 clinical trials per year. Its research department boasts more than 1,800 active inventions. "Clinical trainees and grad students work closely together," said Surgical Innovations engineering lead Shuvo Roy, PhD. "We also have post-doc engineers who move technology from bench to clinical studies." Surgical Innovations evolved out of UCSF's Pediatric Device Consortium (PDC), which creates and develops devices to improve children's health. Michael Harrison, MD, who founded and leads PDC, pioneered fetal surgery procedures at UCSF in the early 1980s. "Th...
Source: MDDI - Category: Medical Devices Authors: Tags: R & D Source Type: news

Related Links:

Publication date: Available online 23 March 2019Source: NeuroImageAuthor(s): Sharmili Edwin Thanarajah, Sandra Iglesias, Bojana Kuzmanovic, Lionel Rigoux, Klaas E. Stephan, Jens C. Brüning, Marc TittgemeyerAbstractInsulin modulates dopamine neuron activity in midbrain and affects processes underlying food intake behaviour, including impulsivity and reward processing. Here, we used intranasal administration and task-free functional MRI in humans to assess time- and dose-dependent effects of insulin on functional connectivity of the dopaminergic midbrain – and how these effects varied depending on systemic insulin...
Source: NeuroImage - Category: Neuroscience Source Type: research
CONCLUSIONS: Polypharmacy is significantly associated with delirium only in surgical units, raising the issue of the relevance of medication review in different clinical settings. Specific drug classes are associated with delirium depending on the clinical setting and dementia diagnosis, suggesting the need to further explore this relationship. PMID: 30901165 [PubMed - in process]
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
CONCLUSIONS: The large, sustained improvements in weight and diabetes observed in this self-selected sample of surgically treated participants are consistent with results of multiple randomized trials. PMID: 30900413 [PubMed - in process]
Source: Obesity - Category: Eating Disorders & Weight Management Authors: Tags: Obesity (Silver Spring) Source Type: research
Abstract OBJECTIVE: The aim of this study was to test associations of prepregnancy BMI, gestational weight gain, oral glucose challenge test results, and postpartum weight loss as predictors of breast milk leptin, insulin, and adiponectin concentrations and whether these relationships vary over time. METHODS: Milk was collected at 1 and 3 months from 135 exclusively breastfeeding women from the longitudinal Mothers and Infants Linked for Healthy Growth (MILk) study. Hormones were assayed in skimmed samples using ELISA. Mixed-effects linear regression models were employed to assess main effects and effect...
Source: Obesity - Category: Eating Disorders & Weight Management Authors: Tags: Obesity (Silver Spring) Source Type: research
CONCLUSIONS: PAT+Lifestyle decreases weight gain during pregnancy through 12 months post partum in SED African American women with overweight or obesity at the start of pregnancy with minimal additional cost. PMID: 30900408 [PubMed - in process]
Source: Obesity - Category: Eating Disorders & Weight Management Authors: Tags: Obesity (Silver Spring) Source Type: research
Authors: PMID: 30900407 [PubMed - in process]
Source: Obesity - Category: Eating Disorders & Weight Management Tags: Obesity (Silver Spring) Source Type: research
Publication date: Available online 23 March 2019Source: Redox BiologyAuthor(s): Ersilia Varone, Diego Pozzer, Simona Di Modica, Alexander Chernorudskiy, Leonardo Nogara, Martina Baraldo, Mario Cinquanta, Stefano Fumagalli, Rocio Nur Villar-Quiles, Maria-Grazia De Simoni, Bert Blaauw, Ana Ferreiro, Ester ZitoAbstractSelenoprotein N (SELENON) is an endoplasmic reticulum (ER) protein whose loss of function leads to congenital myopathies associated with insulin resistance (SEPN1-related myopathies). The exact cause of the insulin resistance in patients with SELENON loss of function is not known. Skeletal muscle is the main con...
Source: Redox Biology - Category: Biology Source Type: research
Publication date: Available online 23 March 2019Source: Life SciencesAuthor(s): Elizabeta Zaplatic, Muhammed Bule, Syed Zahid Ali Shah, Md. Sahab Uddin, Kamal NiazAbstractQuercetin belongs to the flavonoids family, which is present in most of the plants including fruits, vegetables, green tea and even in red wine having antioxidant activities. It is available as a food supplement in the market and has physiological health effects. Quercetin has anti-inflammatory, anticancer and anti-prostate activities along with its beneficial effects on high cholesterol, kidney transplantation, asthma, diabetes, viral infections, pulmona...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 23 March 2019Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Rina Kunishige, Fumi Kano, Masayuki MurataAbstractBackgroundCell-based assays are essential for analyzing molecular functions and spatiotemporal information. The cell resealing technique, in which pore-forming toxins are used to permeabilize cell membranes, enables the delivery of various membrane-impermeable molecules inside cells.Scope of reviewWe review the basics of the resealed cell system, including optimized protocols, assessment of cellular damage, and recovery following permeabilization of the m...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research
Authors: Belmar Vega L, Galabia ER, Bada da Silva J, Bentanachs González M, Fernández Fresnedo G, Piñera Haces C, Palomar Fontanet R, Ruiz San Millán JC, de Francisco ÁLM Abstract BACKGROUND: Hyperkalaemia is a significant electrolyte imbalance in chronic kidney disease (CKD). Renin-angiotensin-aldosterone system inhibitors (RAASi) have beneficial cardio-renal properties, although they can often cause hyperkalaemia. OBJECTIVE: To examine the prevalence of hyperkalaemia in CKD, identify factors associated with its appearance and the relationship between hyperkalaemia and mortal...
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
More News: Academia | Allergy & Immunology | Child Development | Children | Clinical Trials | Diabetes | Diabetic Ulcers | Endocrinology | Graduation | Hospitals | Insulin | Laboratory Medicine | Learning | Medical Devices | Nanotechnology | Obstructive Sleep Apnea | Pancreas | Pediatrics | Politics | Pressure Sores | Primary Care | Schools | Skin | Sleep Apnea | Sleep Disorders | Sleep Medicine | Students | Study | Transplant Surgery | Transplants | Universities & Medical Training