Genetic causes of proportionate short stature

Human growth is a very complex phenomenon influenced by genetic, hormonal, nutritional and environmental factors, from fetal life to puberty. Although the GH-IGF axis has a central role with specific actions on growth, numerous genes are involved in the control of stature. Genome-wide association studies have identified>600 variants associated with human height, still explaining a small fraction of phenotypic variation. Since short stature in childhood is a common reason for referral, pediatric endocrinologists must be aware of the multifactorial and polygenic contribution to height.
Source: Best Practice and Research. Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Source Type: research