Methylation-mediated miR-155-FAM133A axis contributes to the attenuated invasion and migration of IDH mutant gliomas

Gliomas with isocitrate dehydrogenases genes mutation (IDHMT) were found to be less aggressive than their wildtype (IDHWT) counterparts. However, the mechanism remains unclear. The current study aims to investigate the role of silenced oncogenic microRNAs in IDHMT gliomas, which were largely ignored and may contribute to the less aggressive behavior of IDHMT gliomas. Microarrays, bioinformatics analysis of the data from TCGA and qPCR analysis of samples from our experimental cohort (LGG: IDHWT=10, IDHMT=31; GBM: IDHWT=34, IDHMT=9) were performed.

Source: Cancer Letters - June 6, 2018 Category: Cancer & Oncology Authors: Guo-Hao Huang, Lei Du, Ningning Li, Ying Zhang, Yan Xiang, Jun-Hai Tang, Shuli Xia, Eric Erquan Zhang, Sheng-Qing Lv Tags: Original Articles Source Type: research