Sleep Spindle Reduction Precedes Seizures by Several Epochs

Sleep and epilepsy have a dynamic reciprocal relationship. Epileptiform discharges are more common in sleep (Malow et al. 1998) and the occurrence of seizures depends on sleep stage (Minecan et al. 2002). We had previously shown that the amount of sleep spindles is reduced before epileptic seizures (Tezer et al. 2014). To understand the time dynamic of this process, we now investigated how long before the seizure this reduction begins.

Source: Clinical Neurophysiology - June 6, 2018 Category: Neuroscience Authors: Jan R émi, Caroline Bubeck, Elisabeth Hartl, F Irsel Tezer, Soheyl Noachtar Tags: Letter to the Editor Source Type: research