Constipation Considerations: News from DDW 2018
Functional constipation —it’s stubborn. Our MD onsite at Digestive Disease Week briefs you on 5 new Dx and Rx approaches.
ConclusionPD-1/PD-L1 inhibitors are generally safer and better tolerated than chemotherapy for patients with NSCLC with regard to summary toxic events, detailed toxic symptoms and hematologic toxicities. However, PD-1/PD-L1 inhibitors can generate a unique spectrum of irAEs, and several of them can be severe and even life-threatening. Clinicians should be aware of the risk of these AEs, as they may have a potentially negative impact on the patients ’ quality of life and survival outcome.
Conclusions: Although there is awareness of the impact of ID, there are some misconceptions regarding age of introduction of complementary feedings, surveillance of Fe status, and side effects of Fe-enriched infant cereals. There is a need for educational initiatives focusing on prevention of Fe deficiency.
Experts at Monash University in Melbourne revealed constipated women having the electric wave therapy were over three times as likely to have two or more bowel movements per week.
CONCLUSION: Patients receiving an opioid-sparing postsurgical pain management protocol with liposomal bupivacaine 266 mg experienced a statistically significant reduction of postsurgical pain and clinically relevant reduction in opioid consumption. The overall incidence of treatment-emergent adverse events was comparable in patients receiving an opioid-sparing postsurgical pain management protocol with or without liposomal bupivacaine. PMID: 30231106 [PubMed - in process]
CONCLUSIONS This study showed that high-dose controlled-release oxycodone could effectively relieve moderate to severe cancer pain, without side effects that were severe enough to result in discontinuation of treatment. PMID: 30229751 [PubMed - in process]
Passing a gentle electric current through the abdomen encourages bowel movements in people with chronic constipation, a clinical trial has found
This study aims to assess the fecal retention in elderly patients using colonic ultrasonography (US) in Japanese long-term care facility and determine the correlation between nutrition management methods and the fecal retention by US. This cross-sectional, single-center study was conducted in a long-term care facility in Japan. Patients with chronic constipation fulfilled the Rome III criteria for the diagnosis of functional constipation. US was performed on constipation patients with 4-day fecal retention before starting the standard management of constipation. After patients had defecated, nurses checked the outside of f...
Postoperative outcomes for Hirschsprung disease (HD) remain variable, with many patients affected by constipation and/or fecal incontinence. The long-term impact upon quality of life (QoL) for HD patients is unclear. We measured long-term QoL outcomes in adolescents with HD using validated questionnaires.
CONCLUSIONIntestinal malrotation is uncommon amongst adults but its complications can be devastating if not recognised early. Ladd’s procedure either laparoscopically or via laparotomy can provide good resolution of symptoms if performed astutely.
CONCLUSION: Elevated MMP-1 and reduced TIMP-1 were found in ODS associated with IRP, which was related to the ODS severity, inflammation and contents of collagen and elastic fibers. PMID: 30221334 [PubMed - as supplied by publisher]