Constipation Considerations: News from DDW 2018

Functional constipation —it’s stubborn. Our MD onsite at Digestive Disease Week briefs you on 5 new Dx and Rx approaches.
Source: ConsultantLive - Category: Internal Medicine Authors: Tags: Conferences/Digestive Disease Week Source Type: news

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Authors: Vijayvargiya P, Camilleri M Abstract INTRODUCTION: Prucalopride is a selective 5-HT4 receptor agonist with colonic prokinetic activity. It was recently approved by the FDA for the treatment of chronic idiopathic constipation. Before this approval, there were limited options to improve colonic motility in the treatment of chronic idiopathic constipation. Areas covered: We systematically searched PubMed, Embase, ClinicalTrials.gov, and international conference presentations, and we reviewed all studies that evaluated prucalopride for the treatment of chronic idiopathic constipation in adults. In this review,...
Source: Expert Review of Clinical Pharmacology - Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research
We describe the protocol for a randomized, patient-assessor-blinded, sham controlled trial. Seventy-two eligible patients will be randomly assigned to the intervention group (acupuncture) or the control group (sham acupuncture). All treatment will be given 26 sessions of acupuncture or sham acupuncture over 8 weeks (5 times per week in the first 2 weeks, 3 times per week during weeks 3-6, and 2 times per week during weeks7 and 8). Each treatment will last for 20 minutes. The primary outcome is the change in mean complete spontaneous bowel movements (CSBMs) per week. The secondary outcomes are patient assessment of constipa...
Source: World Journal of Acupuncture Moxibustion - Category: Complementary Medicine Source Type: research
MiraLAX is a brand-name, over-the-counter product that ’s typically used to treat short-term constipation. It contains polyethylene glycol 3350, which also comes as store-branded generic products. MiraLAX comes as a powder that you mix with liquid to drink. Learn about side effects, warnings, dosage, and more.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Constipation Source Type: news
Publication date: Available online 15 May 2019Source: Surgery (Oxford)Author(s): Narin Suleyman, Freddie CL. BanksAbstractThe initial management of bladder outflow obstruction typically related to benign prostatic hyperplasia (BPH) falls to a large extent within the remit of general practice. Referral onwards to secondary care typically arises following the failure to respond to conservative measures or when complications have supervened; the most significant of which is urinary retention. In the hospital setting, anaesthesia, constipation and immobility are the common precipitants. What follows is a practical guide to the...
Source: Surgery (Oxford) - Category: Surgery Source Type: research
Conclusion: The new field of pediatric PFPT is a safe and effective intervention for children with dyssynergic defecation causing or contributing to chronic constipation, particularly in  children whose comorbidities include anxiety and low ­muscle tone.Dig Dis
Source: Digestive Diseases - Category: Gastroenterology Source Type: research
ConclusionsMultiple myeloma has myriad presentations. Gastrointestinal involvement, although rare, can manifest as small bowel obstruction for which early recognition and appropriate surgical management are key to improving outcome. Intussusception is the most common mechanism of obstruction from extramedullary plasmacytoma causing small bowel obstruction and this has been seen in five of six case reports, including this case. It is important to recognize and consider the risks of immunosuppression, venous thromboembolism, and malnutrition in the surgical management of gastrointestinal complications of multiple myeloma.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Authors: Lang-Illievich K, Bornemann-Cimenti H Abstract Pain therapy often entails gastrointestinal adverse events. While opioids are effective drugs for pain relief, the incidence of opioid-induced constipation (OIC) varies greatly from 15% to as high as 81%. This can lead to a significant impairment in quality of life, often resulting in discontinuation of opioid therapy. In this regard, a good doctor-patient relationship is especially pivotal when initiating opioid therapy. In addition to a detailed history of bowel habits, patient education regarding the possible gastrointestinal side effects of the drugs is cr...
Source: Korean Journal of Pain - Category: Anesthesiology Tags: Korean J Pain Source Type: research
Constipation is often clinically defined as having three or fewer bowel movements a week. Sometimes this is about expectations; people generally feel like they’re not “healthy” if they don’t have a bowel movement every day. But three bowel movements a week can be normal for some people, especially if that has been their pattern for a long time. There are many other factors that affect how people perceive bowel movements. According to the Rome IV criteria of constipation often used in research, frequency alone doesn’t explain all complaints of constipation. Patients complaining of two or more o...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Complementary and alternative medicine Digestive Disorders Health Source Type: blogs
Publication date: Available online 15 May 2019Source: Journal of EthnopharmacologyAuthor(s): Bingyou Yang, Xiaomao Li, Yan Liu, Wei Guan, Haixue KuangAbstractEthnopharmacological relevanceAnemarrhena asphodeloides Bge. Is a traditional Chinese medicine used in treating constipation.Aim of the study: To investigate the laxative activities and the potential mechanism of polysaccharides obtained from Anemarrhena asphodeloides Bge. (AABP).Materials and methodsThe experiment was performed using the following techniques: enzyme-linked immuno sorbent assay (ELISA), histopathological, immunohistochemistry, western blotting and rea...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Health information found on open access Internet platforms is often unscrutinized, unreliable, and can lead to considerable morbidity for patients and their presentation to the emergency department. Currently, home treatments for constipation and other gastrointestinal ailments featuring the use of hydrogen peroxide (H2O2) enemas are readily available.
Source: The Journal of Emergency Medicine - Category: Emergency Medicine Authors: Tags: Selected Topics: Toxicology Source Type: research
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