Viability Screen of LOPAC1280 Reveals Phosphorylation Inhibitor Auranofin as Potent Inhibitor of Blastocystis ST1, ST4 and ST7 Isolates.

In this study, LOPAC1280 was screened and drugs that can decrease the viability of three Blastocystis isolates in cultures were identified. Using apoptosis assay and imaging flow cytometry, phenotypic changes in Blastocystis cells after treatment were also analyzed to obtain insights into the possible mechanism of action of these drugs. Three drugs - diphenyleneiodonium chloride, auranofin and BIX 01294 trihydrochloride hydrate, were effective against all three isolates tested. Repurposing of these drugs for Blastocystis treatment could be a way of combatting metronidazole resistance relatively quickly and at a lower cost. PMID: 29866860 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research