Diversity of carbapenemase-producing Escherichia coli isolates, France 2012-2013.

Diversity of carbapenemase-producing Escherichia coli isolates, France 2012-2013. Antimicrob Agents Chemother. 2018 Jun 04;: Authors: Gauthier L, Dortet L, Cotellon G, Creton E, Cuzon G, Ponties V, Bonnin RA, Naas T Abstract With the dissemination of carbapenemase-producing Enterobacteriaceae (CPE) worldwide, carbapenem-hydrolyzing enzymes are increasingly reported among Escherichia coli, the first hospital and community-acquired opportunistic pathogen. Here, we have performed an epidemiological survey of carbapenemase-producing E. coli (CP-Ec) isolates received at the French National Reference Centre (F-NRC) in 2012 and 2013. Antimicrobial susceptibilities for last resort antibiotics and antimicrobial compounds commonly used to treat urinary tract infections were determined by broth microdilution. Clonal relationship was assessed using rep-PCR and MLST typing. From this collection of 140 carbapenemase-producing E. coli, (74%) produced an OXA-48-like carbapenemase followed by NDM (21%). A link with a foreign country was suspected for 37% of infected/colonized patients. Most of the isolates were from screening (56%) and from urine samples (26%). Colistin, fosfomycin and nitrofurantoin possessed the most consistent activity with 100%, 95% and 96% of susceptibility, respectively. A wide diversity of carbapenemase-producing E. coli isolates has been found (50 different STs). The most prevalent clones were (i) E. coli ST38 producing-OXA-4...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research