Zika Virus VLP (Virus-like Particle) Antigens for Vaccine Candidate and Diagnostic Development
Zika virus (ZIKV) is a flavivirus primarily transmitted by infected Aedes mosquitoes. Infection with ZIKV during pregnancy can affect the fetus causing microcephaly, neurological complications, and other birth defects. Adults are also at a heightened risk of developing Guillain-Barre syndrome and other neurological disorders. In response to the 2015-2016 Zika outbreak, CDC scientists developed a recombinant vaccine candidate as well as reagents and methods to detect ZIKV infection. The recombinant vaccine candidate utilizes adenovirus vector expressed viral envelope proteins. This vector-based vaccine candidate is an efficient platform that elicits a strong response in mouse models; added vaccine testing in rabbit models is underway. Virus-like particles generated from the vector are also being used for ZIKV diagnostics. The US Food and Drug Administration (FDA) has issued an Emergency Use Authorization (EUA) for CDC's Zika IgM antibody capture enzyme-linked immunosorbent assay (Zika MAC-ELISA) that utilizes VLP technology for in vitro qualitative detection of human IgM antibodies to Zika virus in serum. It can also be used to test cerebrospinal fluid (CSF) when submitted with a patient-matched serum sample. The CDC Zika MAC-ELISA assay is currently in use at qualified laboratories designated by CDC.IC: CDCNIH Ref. No.: E-107-2016-0Advantages: VLP strategy has proven to be very effective inCDC's West Nile virus (WNV) and dengue vaccine developmentVaccine resear...
Authors: Fukushima K, Yanagisawa N, Sekiya N, Izumiya H Abstract Non-typhoidal Salmonella (NTS) infection is a major pathogen causing gastroenteritis among immunocompetent adults. NTS infection is mainly transmitted by contaminated food and water, but some cases are transmitted by animal contact. Salmonella enterica subsp. enterica serovar Poona (S. Poona) is an NTS usually transmitted by reptiles, and cases including outbreaks of gastroenteritis have been reported previously. However, invasive infections due to this organism among immunocompetent adults are rare. We herein report a case of a 39-year-old man who wa...
Abstract Uterine radial artery resistance index (URa-RI) by Doppler ultrasound may reflect the changes in the uteroplacental circulation and be associated with adverse events in early pregnancy. Recurrent pregnancy losses (RPL) are associated with thrombophilia, and anticoagulation treatment with low molecular weight heparin improves pregnancy outcome in women with RPL and thrombophilia. A retrospective cohort study was conducted in 139 pregnant women with 3 or more RPL and thrombophilia. The relationship between pregnancy outcome and dynamic changes of URa-RI was analyzed in 116 women who delivered a liveborn inf...
ConclusionIn women with endometrial polyps, the prevalence of CE in infertile women is higher than that in fertile women. Pregnancy outcome in infertile women with treated CE was similar to those who were infertile and without CE.
Conclusions: The AS04-adjuvanted HPV-16/18 vaccine administered according to a 2-dose schedule to girls 4–6 years of age induced a high and sustained immunologic response with an acceptable safety profile during the 30 months following vaccination.
Conclusions: The PHiD-CV vaccination program in Brazil has resulted in important reductions of pneumococcal disease and substantial cost savings. Instead of switching PCVs, expanding vaccine coverage or investing in other health care interventions would be a more efficient use of resources to improve the health of the population in Brazil.
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Publication date: October 2019Source: Annals of Emergency Medicine, Volume 74, Issue 4Author(s): Lauren Westafer