Birthweight, Type 2 Diabetes Mellitus, and Cardiovascular Disease: Addressing the Barker Hypothesis With Mendelian Randomization [Original Articles]

Conclusions:
Our study indicates that lower birthweight, used as a proxy for intrauterine growth retardation, is causally related with increased susceptibility to coronary artery disease and T2D. This causal relationship is not mediated by adult obesity or hypertension.

Source: Circulation: Cardiovascular Genetics - June 6, 2018 Category: Cardiology Authors: Zanetti, D., Tikkanen, E., Gustafsson, S., Priest, J. R., Burgess, S., Ingelsson, E. Tags: Genetics Original Articles Source Type: research