Biomarker-Calibrated Total Sugars Intake and Risk of Type 2 Diabetes and Cardiovascular Disease in the Women's Health Initiative Observational Study.

Biomarker-Calibrated Total Sugars Intake and Risk of Type 2 Diabetes and Cardiovascular Disease in the Women's Health Initiative Observational Study. Am J Epidemiol. 2018 Jun 04;: Authors: Tasevska N, Pettinger M, Kipnis V, Midthune D, Tinker LF, Potischman N, Neuhouser ML, Beasley JM, Van Horn L, Howard BV, Liu S, Manson JE, Shikany JM, Thomson CA, Prentice RL Abstract The inconsistent findings from epidemiologic studies relating total sugars (TS) consumption to cardiovascular disease (CVD) or type 2 diabetes (T2D) risk may be partly due to measurement error (ME) in self-reported intake. Using regression calibration equations developed based on the predictive biomarker for TS and recovery biomarker for energy, we examined the association of TS with T2D and CVD risk, before and after dietary calibration, in 82,254 postmenopausal women of the Women's Health Initiative-Observational Study. After up to 16 years of follow-up (1993-2010), 6,621 T2D and 5,802 CVD incident cases were identified. The hazard ratio (HR) for T2D per 20% increase in calibrated TS was 0.94 (95% CI: 0.77, 1.15) in multivariable energy substitution (ES), and 1.00 (0.85, 1.18) in energy partition (EP) models. Multivariable HRs for total CVD were 0.97 (0.87, 1.09) from ES, and 0.91 (0.80, 1.04) from EP models. Uncalibrated TS generated a statistically significant inverse association with T2D and total CVD risk in both multivariable ES and EP models. The lack of concl...
Source: Am J Epidemiol - Category: Epidemiology Authors: Tags: Am J Epidemiol Source Type: research