Scientists map genetic codes of 3,000 dangerous bacteria

The DNA of deadly strains of plague, dysentery and cholera were decoded in what the researchers said was an effort to better understand some of the world's most dangerous diseases.
Source: CBC | Health - Category: Consumer Health News Tags: News/Health Source Type: news

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Abstract Type III secretion systems (T3SS) can be found in many pathogenic bacteria, such as Dysentery bacillus, Salmonella typhimurium, Vibrio cholera and pathogenic Escherichia coli. The routes of infection of these bacteria include the T3SS transferring a large number of type III secreted effectors (T3SE) into host cells, thereby blocking or adjusting the communication channels of the host cells. Therefore, the accurate identification of T3SEs is the precondition for the further study of pathogenic bacteria. In this article, a new T3SEs ensemble predictor was developed, which can accurately distinguish T3SEs fr...
Source: Briefings in Bioinformatics - Category: Bioinformatics Authors: Tags: Brief Bioinform Source Type: research
DiscussionExpanding the treatment of acute watery diarrhoea in high-risk children to include an antibiotic may offer an opportunity to reduce deaths. These benefits may result from direct antimicrobial effects on pathogens or other incompletely understood mechanisms including improved nutrition, alterations in immune responsiveness or improved enteric function. The expansion of indications for antibiotic use raises concerns about the emergence of antimicrobial resistance both within treated children and the communities in which they live. ABCD will monitor antimicrobial resistance. The ABCD trial has important policy impli...
Source: Trials - Category: Research Source Type: clinical trials
AbstractIn acute gastroenteritis (AGE), identification of the infectious agent is important for patient management. Since symptoms do not reliably identify the agent, microbiological diagnostics are important. Conventional methods lack sensitivity and often take days. Multiplex PCR panels offer fast and sensitive alternatives. Our aim was to assess the performance of the new QIAstat Gastrointestinal Panel (GIP) detecting 24 different gastroenteric pathogens from stool in Cary-Blair transport medium (Adenovirus F 40/41, Astrovirus, Norovirus GI/GII, Rotavirus A, Sapovirus,Campylobacter spp.,Clostridium difficile,Plesiomonas...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Abstract Diarrhea remains one of the top five causes of disease and death among young children in developing nations. Fortunately, scientists are making progress developing vaccines against enterotoxigenic E. coli (ETEC) and Shigella, two of the leading diarrhea pathogens. As vaccine developers start to consider field efficacy trials of these vaccines, they should be aware of the importance of evaluating not only vaccine direct effects on the immunized, but also the herd effects that vaccination can afford to the unimmunized in a community. In a workshop held at the conference titled "Vaccines against Shigell...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Date: Wednesday, 08 07, 2019; Speaker: Edward T. Ryan, M.D., Director of Global Infectious Diseases, Massachusetts General HospitalBoston, MA; Building 8 1st floor conference room; 123-127
Source: NIH Calendar of Events - Category: American Health Source Type: events
IJERPH, Vol. 16, Pages 2052: Assessing Students’ Knowledge on WASH-Related Diseases International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16112052 Authors: Khaldoon A. Mourad Vincent Habumugisha Bolaji F. Sule Water-, sanitation-, and hygiene-related diseases are killing many people each year in developing countries, including Rwanda, and children under the age of five are the most vulnerable. This research assessed human waste disposal practices, knowledge on diseases caused by contact with human faeces, and knowledge on causes and prevention of selected WASH-related diseas...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
In conclusion, the mouse pharyngeal colonization model is an affordable and accessible experimental system that allows a broader group of research groups to test the importance of their findings in an in vivo model. There is a great deal of overlap between the bacterial and immune factors found to be important in human and murine pharyngeal colonization. Although MHC-II humanized mice could prove useful in answering certain questions, the use of inbred mouse lines appears to be sufficient for evaluation of most questions, both related to bacterial factors and the host immune response. However, when promising treatments or ...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
In this study, 12 O-antigen gene clusters of P. shigelloides, O2H1a1c (G5877), O10H41 (G5892), O12H35 (G5890), O23H1a1c (G5263), O25H3 (G5879), O26H1a1c (G5889), O32H37 (G5880), O33H38 (G5881), O34H34 (G5882), O66H3 (G5270), O75H34 (G5885), and O76H39 (G5886), were sequenced and analyzed. The genes that control O-antigen synthesis are present as chromosomal gene clusters that maps between rep and aqpZ, and most of the synthesis and translocation of OPS (O-specific polysaccharide) belongs to Wzx/Wzy pathway with the exception of O12, O25, and O66, which use the ATP-binding cassette (ABC) transporter pathway. Phylogenetic an...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
[Thomson Reuters Foundation] Nairobi -At least half a million survivors of a powerful cyclone in southeast Africa are at risk of fatal diseases, from cholera and dysentery to malaria, aid workers warned on Thursday, as rescue teams struggled to reach flood-hit communities.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
This study aims to investigate the antimicrobial activity of C. zeylanica leaf extracts against pathogenic microorganisms, with the interactions of potential compounds being predicted by a computational approach. Ethyl acetate leaf extracts of C. zeylanica were evaluated for antimicrobial activity using an agar well diffusion method against pathogenic microorganisms (Staphylococcus epidermidis, Enterococcus faecalis, Salmonella paratyphi, Shigella dysenteriae, and Mycobacterium tuberculosis and Candida albicans). The ethyl acetate leaf extracts of the C. zeylanica were utilized for GC-MS analysis. Computational studies wer...
Source: Analytical Biochemistry - Category: Biochemistry Authors: Tags: Anal Biochem Source Type: research
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