Work stress raises risk of premature death in vulnerable men - study

Men with diabetes or heart disease under ‘job strain’ have 68% higher risk of early deathA major study into the impact of work stress on health has revealed dramatic differences in the rates of premature death between different groups of men, and between men and women, depending on existing medical conditions.Doctors found that men with diabetes, heart disease, or who had previously suffered a stroke, were 68% more likely to die over the course of the study if they had demanding jobs with little control over their workload.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Health Science Diabetes Mental health Heart disease Medical research Men's health & wellbeing Work-life balance careers Source Type: news

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This study aims to determine methodological variations in the event simulation approaches of published health economic decision models, in the field of obesity, and to investigate whether their predictiveness and validity were investigated via external event validation techniques, which investigate how well the model reproduces reality. Areas covered: A systematic review identified a total of 87 relevant papers, of which 72 that simulated obesity-associated events were included. Most frequently simulated events were coronary heart disease (≈83%), type 2 diabetes (≈74%), and stroke (≈66%). Only for ten pub...
Source: Expert Review of Pharmacoeconomics and Outcomes Research - Category: Health Management Tags: Expert Rev Pharmacoecon Outcomes Res Source Type: research
Conclusions: This result represents the first genetic evidence in a large cohort for the protective effect of PCSK9 inhibition on ischemic stroke and corroborates exploratory evidence from clinical trials. PCSK9 inhibition was not associated with variables other than those related to LDL (low-density lipoprotein) cholesterol, atherosclerosis, and type 2 diabetes mellitus, suggesting that other effects are either small or absent.
Source: Circulation: Cardiovascular Genetics - Category: Cardiology Authors: Tags: Cardiovascular Disease, Diabetes, Type 2, Genetic, Association Studies, Ischemic Stroke Original Articles Source Type: research
Publication date: May 2018Source: Advances in Chronic Kidney Disease, Volume 25, Issue 3Author(s): Forrest H. NielsenAlthough official magnesium (Mg) dietary reference intakes are open to question, a significant number of adults likely have intakes that are in the range of 50%-99% of the requirement. This moderate or marginal (subclinical) deficient Mg intake generally is asymptomatic. Animal studies, however, indicate that moderate or subclinical Mg deficiency primes phagocytic cells for the release of proinflammatory cytokines leading to chronic inflammatory and oxidative stress. Human studies have found that dietary Mg ...
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research
Publication date: June 2018Source: The Lancet Global Health, Volume 6, Issue 6Author(s): Ben Lacey, Sarah Lewington, Robert Clarke, Xiang Ling Kong, Yiping Chen, Yu Guo, Ling Yang, Derrick Bennett, Fiona Bragg, Zheng Bian, Shaojie Wang, Hua Zhang, Junshi Chen, Robin G Walters, Rory Collins, Richard Peto, Liming Li, Zhengming Chen, Junshi Chen, Zhengming ChenSummaryBackgroundThe age-specific association between blood pressure and vascular disease has been studied mostly in high-income countries, and before the widespread use of brain imaging for diagnosis of the main stroke types (ischaemic stroke and intracerebral haemorrh...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
ConclusionsA diet featuring high food variety, high fish intake, and low sugar intake was negatively associated with the prevalence of cardiovascular outcomes among Inuit.
Source: Journal of the Academy of Nutrition and Dietetics - Category: Nutrition Source Type: research
Publication date: July 2018Source: The Lancet Diabetes &Endocrinology, Volume 6, Issue 7Author(s): L Gnatiuc, WG Herrington, J Halsey, J Tuomilehto, X Fang, HC Kim, D De Bacquer, AJ Dobson, MH Criqui, DR Jacobs, DA Leon, SAE Peters, H Ueshima, P Sherliker, R Peto, R Collins, RR Huxley, JR Emberson, M Woodward, S LewingtonSummaryBackgroundSeveral studies have shown that diabetes confers a higher relative risk of vascular mortality among women than among men, but whether this increased relative risk in women exists across age groups and within defined levels of other risk factors is uncertain. We aimed to determine wheth...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 5 June 2018Source: The Lancet Diabetes &EndocrinologyAuthor(s): Mika Kivimäki, Jaana Pentti, Jane E Ferrie, G David Batty, Solja T Nyberg, Markus Jokela, Marianna Virtanen, Lars Alfredsson, Nico Dragano, Eleonor I Fransson, Marcel Goldberg, Anders Knutsson, Markku Koskenvuo, Aki Koskinen, Anne Kouvonen, Ritva Luukkonen, Tuula Oksanen, Reiner Rugulies, Johannes Siegrist, Archana Singh-ManouxSummaryBackgroundAlthough some cardiovascular disease prevention guidelines suggest a need to manage work stress in patients with established cardiometabolic disease, the evidence base for this...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
ConclusionsThere are large gaps in the use of proven medications for secondary prevention of cardiovascular disease in South America. Strategies to improve the sustained use of these medications will likely reduce cardiovascular disease burden substantially.
Source: Global Heart - Category: Cardiology Source Type: research
Publication date: Available online 31 January 2018Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Ing-Kit Lee, Ching-Jung Hsieh, Chien-Te Lee, Jien-Wei LiuAbstractBackground/purposeThe impact of type 2 diabetes mellitus (DM2) on clinical severity of dengue has not been fully understood. We aimed to assess risk factors for dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) and severe dengue (SD) (defined based on the World Health Organization 1997 and 2009 dengue classifications), and additionally identify, among DM2 patients, who are at risk for developing DHF/DSS and severe dengue.MethodsA retr...
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
ConclusionTotal potato consumption is not related to risk for many chronic diseases but could pose a small increase in risk for T2D if consumed boiled. A clear risk relation was found between French-fries consumption and risk of T2D and hypertension. For several outcomes, the impact of different preparation procedures could not be assessed.
Source: European Journal of Nutrition - Category: Nutrition Source Type: research
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