Management of HCV-Related Liver Disease in Hemophilia and Thalassemia

Semin Liver Dis 2018; 38: 112-120 DOI: 10.1055/s-0038-1655774Chronic infection with the hepatitis C virus (HCV) has long been the dominant complication of substitution therapy in patients with inherited blood disorders and the cause of anticipated death due to end-stage liver disease. In hemophilia, transmission of HCV with clotting factors concentrates started to be curbed in the mid-1980s following the adoption of procedures of virus inactivation of concentrates based on heat, whereas in the 1990s treatment of HCV infection with interferon monotherapy was attempted, however, with little success. The advent of combination therapy of interferon with ribavirin led to a substantial improvement of treatment outcome (40% rate of cure), that however was still of limited efficacy in patients with advanced liver disease, those with high load of HCV genotype 1, and patients coinfected with the human immunodeficiency virus. In this latter population, while the course of hepatitis C was accelerated as a consequence of immunodeficiency, the advent of highly active antiretroviral therapy led acquired immunodeficiency syndrome (AIDS) to decline and hepatitis C to progressively emerge as a dominant cause of mortality, in parallel. In patients with thalassemia, transfusion-related transmission of HCV was efficiently interrupted in 1992 with the advent of sensitive screening tests for testing donors for HCV, whereas treatment with interferon and ribavirin of infected thalassemics was constra...
Source: Seminars in Liver Disease - Category: Gastroenterology Authors: Tags: Review Article Source Type: research

Related Links:

This study aimed to evaluate the effects of LLV on HCC development, mortality, and cirrhotic complications among patients according to their adherence to entecavir (ETV) treatment. Methods: We performed a retrospective observational analysis of data from 894 consecutive adult patients with treatment-naïve CHB undergoing ETV treatment. LLV was defined according to either persistent or intermittent episodes of
Source: Clinical and molecular hepatology - Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research
Authors: Woo HY, Park JY, Bae SH, Kim CW, Jang JY, Tak WY, Kim DJ, Kim IH, Heo J, Ahn SH Abstract Background/Aims: Suboptimal responses to lamivudine or telbivudine plus adefovir (LAM/LdT+ADV) rescue therapy are common in patients with LAM-resistant hepatitis B virus (HBV) infections. We compared patients switched to entecavir plus tenofovir (ETV+TDF) to those maintained on LAM/LdT+ADV. Methods: This prospective randomized controlled trial examined 91 patients whose serum HBV DNA levels were greater than 60 IU/mL after at least 24 weeks of treatment with LAM/LdT+ADV for LAM-resistant HBV. Patients were randomiz...
Source: Clinical and molecular hepatology - Category: Gastroenterology Tags: Clin Mol Hepatol Source Type: research
Did you know diabetes affects your mental health? From depression to relationship problems or mood swings, too much or too little glucose (sugar) circulating in the blood can trigger behavior and thought patterns that may seem unrelated to how much insulin is released by your pancreas. Out of control glucose levels influence how you feel and make decisions, your beliefs and, yes, your attitude, a very necessary component of your overall care.  The U.S. Centers for Disease Control and Prevention (CDC) states less than half the number of people with diabetes who have depression get treated, which leads to worsening stat...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Mental Health and Wellness Comorbidities Diabetes Drug Interactions Nutrition Source Type: blogs
Considering that female sexual hormones may modulate the inflammatory response and also exhibit direct effects on the cells of the immune system, herein, we intend to discuss the sex differences and the role of estradiol in modulating the lung and systemic inflammatory response, focusing on its possible application as a treatment modality for SARS-CoV-2 patients. COVID-19 patients develop severe hypoxemia early in the course of the disease, which is silent most of the time. Small fibrinous thrombi in pulmonary arterioles and a tumefaction of endothelial were observed in the autopsies of fatal COVID-19 cases. Studies showed...
Source: Clinics - Category: General Medicine Source Type: research
Publication date: Available online 25 May 2020Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Ludy Vargas, Fernanda Bastos, André Guimarães, Sávio Amaral, Tarcisio Fausto, Maria Arriaga, Manoel Sarno, Carlos Brites
Source: The Brazilian Journal of Infectious Diseases - Category: Infectious Diseases Source Type: research
CONCLUSION: MiR-98-5p inhibits the secretion of HBV, proliferation, migration, and invasion of HBV-HCC cells by targeting NIK. PMID: 32469170 [PubMed - in process]
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
This study is aimed at determining the prevalence of immunologic and clinical antiretroviral treatment failure. Methods: A cross-sectional study design using clinical and immunologic treatment failure definition was used to conduct the study. Sociodemographic characteristics and clinical features of patients were retrieved from patients' medical registry between the years 2009 and 2015. All patients who fulfilled the inclusion criteria in the study period were studied. Predictors of treatment failure were identified using Kaplan-Meier curves and multivariable Cox regression analysis. Data analysis was done using SPSS ...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
This study was aimed at determining the incidence and the onset of hepatotoxicity and at evaluating the relationship of some risk factors for hepatotoxicity among Human Immunodeficiency Virus- (HIV-) positive, tuberculosis (TB), and HIV/TB patients on treatment. This was a prospective follow-up study involving 125 participants from the HIV/AIDS and TB treatment centres in three hospitals in Fako Division of Cameroon. These TB and HIV patients were initiated on RHEZ (R = Rifampicin, H = Isoniazid, E = Ethambutol, and P = Pyrazinamide) and TELE (efavirenz/tenofovir/lami...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Founded during the AIDS crisis, God's Love We Deliver is a charity committed to feeding homebound New Yorkers afflicted with disease. Decades later with another pandemic affecting the country, the charity is working nonstop to meet the spike in demand amid the coronavirus crisis. Anthony Mason speaks to God's Love CEO Karen Pearl.
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
Authors: Stefano ML, Kream RM, Stefano GB Abstract The emergence of the novel ß-coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a global pandemic of coronavirus disease 2019 (COVID-19). Clinical studies have documented that potentially severe neurological symptoms are associated with SARS-CoV-2 infection, thereby suggesting direct CNS penetration by the virus. Prior studies have demonstrated that the destructive neurological effects of rabies virus (RABV) infections are mediated by CNS transport of the virus tightly bound to the nicotinic acetylcholine receptor (nACh...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
More News: Anemia | Gastroenterology | Haemophilia | Hemophilia | Hepatitis | Hepatitis C | Highly Active Antiretroviral Therapy | HIV AIDS | Liver | Liver Disease | Urology & Nephrology