Integrated genomic characterization of oral carcinomas in post-hematopoietic stem cell transplantation survivors

Successes in hematopoietic stem cell transplantation (HSCT) over the last few decades to cure many patients of their underlying hematologic malignancies has resulted in a surge of patients followed long-term. To that end, it has become increasingly recognized that the risk of secondary cancers in survivors of allogeneic HSCT is high [1]. The most frequent secondary cancer is squamous cell carcinoma (SCC) of the oral cavity, representing a 16-fold higher risk among HSCT patients compared with the general population [2].

Source: Oral Oncology - April 10, 2018 Category: Cancer & Oncology Authors: Glenn J. Hanna, Eric R. Kofman, Muhammad Ali Shazib, Sook-bin Woo, Brendan Reardon, Nathaniel S. Treister, Robert I. Haddad, Corey S. Cutler, Joseph H. Antin, Eliezer M. Van Allen, Ravindra Uppaluri, Robert J. Soiffer Source Type: research