Distinguishing neurocognitive deficits in adult patients with NP-C from early onset Alzheimer ’s dementia

Niemann-Pick disease type C (NP-C) is a rare, progressive neurodegenerative disease caused by mutations in the NPC1 or the NPC2 gene. Neurocognitive deficits are common in NP-C, particularly in patients with the ...
Source: Orphanet Journal of Rare Diseases - Category: Internal Medicine Authors: Tags: Research Source Type: research

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ConclusionVascular surgery in TA cases becomes an option when the patient does not improve clinically after administration of medical treatment. Although endovascular management has fewer complications, the rate of restenosis is higher. Patients at risk of restenosis and who have increased perioperative vascular risk can benefit from open surgical procedures. Surgical management should be tailored to the patient’s needs.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
In this study, we aimed to develop a risk prediction model to predict fast decline in the Aβ + MCI population using multimodal biomarkers. We included 186 Aβ + MCI patients who underwent florbetapir PET, brain MRI, cerebrospinal fluid (CSF) analyses, and FDG PET at baseline. We defined conversion to dementia within 3 years (= fast decline) as the outcome. The associations of potential covariates (MCI stage, APOE4 genotype, corrected hippocampal volume (HV), FDG PET SUVR, AV45 PET SUVR, CSF Aβ, total tau (t-tau), and phosphorylated tau (p-tau)) with the outcome were tested and nomograms were constru...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 19 July 2019Source: Clinica Chimica ActaAuthor(s): Giulia Bivona, Bruna Lo Sasso, Giorgia Iacolino, Caterina Maria Gambino, Concetta Scazzone, Luisa Agnello, Marcello CiaccioAbstractThe current review provides an overview on the development of 25(OH)D measurement standardization tools over the last three decades and clarifies whether there is a role as a serum biomarker for vitamin D in neurological diseases. In the past, a lack of internationally recognized 25(OH)D reference measurement procedures and reference standard materials led to unstandardized serum total 25(OH)D results among re...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
In this study, to identify the differentially gut-liver-brain axis among APP/PS1 mice, FSS-treated APP/PS1 mice, and control mice, behavioral tests were performed to assess the cognitive ability and hematoxylin-eosin staining was used to assess neuronal damage in the hippocampus; immunohistochemistry, western blotting, a quantitative chromogenic end-point Tachypleus amebocyte lysate (TAL) assay kit, Malondialdehyde (MDA) assay kit, AP Assay Kit, and real-time quantitative PCR (qPCR) were used to assess the level of LPS, MDA, AP, and gut bacteria. We found that FSS regulates gut-liver-brain axis to regulate AP and gut bacte...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
An artificial intelligence-enabled video fall detection system using visual science reduced emergency department visits by 80% in 6 communities over 3 months. Language: en...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
AbstractWhen managing behavioural changes in individuals with dementia in long-term care settings, non-pharmacological approaches should be the first-line option. However, evidence indicates that psychotropic medications are prescribed excessively in this patient population. Psychotropics can be successfully deprescribed by gradually withdrawing treatment, by taking a person-centred approach that actively involves residents, their family/support persons and multidisciplinary teams, by ensuring healthcare staff are well trained and supported by management, and by employing effective communication strategies.
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research
The objective of the study was to understand respondents' willingness to accept hypothetical treatment-related risks in return for the benefit of additional time with normal memory from potential Alzheimer's disease interception therapies.
Source: Value in Health - Category: International Medicine & Public Health Authors: Source Type: research
AbstractThe field of thyroid hormone signaling has grown more complex in recent years. In particular, it has been suggested that some thyroid hormone derivatives, tentatively named “novel thyroid hormones” or “active thyroid hormone metabolites”, may act as independent chemical messengers. They include 3,5-diiodothyronine (T2), 3-iodothyronamine (T1AM), and several iodothyroacetic acids, i.e., 3,5,3’,5’-thyroacetic acid (TA4), 3,5,3’-thyroacetic acid (TA3), and 3 -thyroacetic acid (TA1). We summarize the present knowledge on these compounds, namely their biosynthetic pathways, endo...
Source: Endocrine - Category: Endocrinology Source Type: research
Photo credit Chuttersnap It's not hard to understand why 60-year-olds would say that they want to remain in their home for life rather than move to assisted living or a nursing home. These are generally people who are relatively healthy and feel that they can hire help for whatever they need down the road. Indeed, aging in place sounds like a wonderful concept. What could possibly be wrong with it?  Read more on HealthCentral to learn about the pros and cons of assisted living vs. aging-in-place: Carol Bradley Bursack is the Candid Caregiver MedicareFAQ – Medicare Resource Center Support a caregiver or jump...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
AbstractExpression of the transient receptor potential ankyrin 1 (TRPA1) receptor has been demonstrated not only in the dorsal root and trigeminal ganglia but also in different brain regions (e.g., hippocampus, hypothalamus, and cortex). However, data concerning their role in neurodegenerative and age-related diseases of the CNS is still indistinct. The aim of our study was to investigate the potential role of TRPA1 in a mouse model of senile dementia. For the investigation of changes during aging, we used male young (3 –4-month-old) and old (18-month-old) wild-type (TRPA1+/+;WT) and TRPA1 receptor gene-deleted (TRPA...
Source: AGE - Category: Geriatrics Source Type: research
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