Hepatocyte spheroids as an alternative to single cells for transplantation after ex vivo gene therapy in mice and pig models

Autologous hepatocyte transplantation after ex vivo gene therapy is an alternative to liver transplantation for metabolic liver disease. Here we evaluate ex vivo gene therapy followed by transplantation of single-cell or spheroid hepatocytes.

Source: Surgery - June 5, 2018 Category: Surgery Authors: Clara T. Nicolas, Raymond D. Hickey, Kari L. Allen, Zeji Du, Rebekah M. Guthman, Robert A. Kaiser, Bruce Amiot, Aditya Bansal, Mukesh K. Pandey, Lukkana Suksanpaisan, Timothy R DeGrado, Scott L. Nyberg, Joseph B. Lillegard Source Type: research