Micro-RNA-181a suppresses progestin-promoted breast cancer cell growth

Breast cancer (BC) is one of the most common invasive cancers in women worldwide, comprising 22.9% of invasive cancers, and is the second main cause of cancer death in women [1]. Based on clinical studies, synthetic progestogens (also called progestins) may play a crucial role in the development of BC with the use of contraception and hormone therapy in reproductive and menopausal women [2]. Norethisterone (NET), a progestin, is a medication used in combination with estrogen or alone in hormone therapy.

Source: Maturitas - June 5, 2018 Category: Primary Care Authors: Muqing Gu, Lijuan Wang, Chun Yang, Xue Li, Chanwei Jia, Stephane Croteau, Xiangyan Ruan, Pierre Hardy Source Type: research