Naive B Cells with High-Avidity Germline-Encoded Antigen Receptors Produce Persistent IgM+ and Transient IgG+ Memory B Cells

Immunity induced by certain vaccines declines over time. By studying B cell responses to phycoerythrin, Pape et  al. find that memory B cells can be short-lived when generated from precursors that experience unusually strong early signals through their un-mutated antigen receptors.

Source: Immunity - June 5, 2018 Category: Allergy & Immunology Authors: Kathryn A. Pape, Robert W. Maul, Thamotharampillai Dileepan, Amanda Schmidt Paustian, Patricia J. Gearhart, Marc K. Jenkins Tags: Article Source Type: research