Evidence Growing Metformin Safe in Many With Diabetes and CKD Evidence Growing Metformin Safe in Many With Diabetes and CKD

Rates of acidosis comparable in metformin-treated and nontreated patients with type 2 diabetes and mild to moderate chronic kidney disease when eGFR is at least 30 mL/min/1.73 m2.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

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Publication date: Available online 20 June 2018Source: Canadian Journal of DiabetesAuthor(s): Stephany I. Adame Perez, Peter A. Senior, Catherine J. Field, Kailash Jindal, Diana R. MagerAbstractObjectivesFrailty can cause increased vulnerability to adverse health outcomes, such as falls, fractures, depression and reduced health-related quality of life (HRQoL). This cross-sectional study compared the differences in body composition, HRQoL, mental health and cognitive and vitamin D (vitD) status with health-care utilization by frail and nonfrail adults with diabetes mellitus (type 1 and type 2) and with chronic kidney diseas...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Authors: Kim KS, Park SW, Cho YW, Kim SK Abstract BACKGROUND: To evaluate the prevalence of chronic kidney disease (CKD) and progression rate to CKD in elderly patients with type 2 diabetes mellitus (T2DM). METHODS: We investigated the medical records of 190 elderly patients (65 years or older) with T2DM from 2005 to 2011 in 6-month increments. Mean follow-up duration was 64.5 months. CKD was defined as estimated glomerular filtration rate (eGFR)
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
AbstractAimsType 2 diabetes (T2D) accelerates the decline in glomerular function; however, some individuals do not develop chronic kidney disease despite advanced age and long-lasting T2D. We aimed to phenotype patients with T2D aged 80  years or older who presented with a fully preserved kidney function.MethodsFrom an Italian population of 281,217 T2D outpatients, we collected data on demographics, anthropometrics, diabetes duration, HbA1c, fasting plasma glucose, lipids, liver enzymes, estimated glomerular filtration rate (eGFR), albumin excretion rate (AER), chronic complications, and medication use. We primarily c...
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
Victorine B Nzana, Anusha Rohit, Deepu George, Madhusudan Vijayan, Milly Mathew, Sundar Sankaran, Palaniappan Nagarajan, Georgi AbrahamIndian Journal of Medical Microbiology 2018 36(2):282-284A 51-year-old female, with non-alcoholic liver cirrhosis, portal hypertension, type 2 diabetes mellitus, autosomal dominant polycystic kidney disease with a clipped cerebral aneurysm and chronic kidney disease stage 5 was on continuous ambulatory peritoneal dialysis (CAPD) for 6.5 years elsewhere. She came for opinion on continuation of CAPD as she had 21 episodes of peritonitis in 76 months. Her blood pressure was 80/50 mmHg. She was...
Source: Indian Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research
Publication date: Available online 1 August 2018Source: Alexandria Journal of MedicineAuthor(s): Richard K.D. Ephraim, Richard Mantey, Stephen Atombo, Samuel A. Sakyi, Linda A. Fondjo, Worlanyo Tashie, Hope Agbodzakey, Felix A. Botchway, Bright AmankwaaAbstractBackgroundChronic kidney disease (CKD), has become a public health concern as it has been reported to cause adverse outcomes such as kidney failure and premature death. This cross sectional study compared the Kidney Disease: Improving Global Outcomes (KDIGO) and Kidney Disease Outcomes Quality Initiative (KDOQI) guidelines in assessing the prevalence of CKD in Type 2...
Source: Alexandria Journal of Medicine - Category: General Medicine Source Type: research
ConclusionsThis study highlights the crucial role that lipids play in the independent development of both NAFLD and CKD and demonstrates the importance of lipid-lowering treatments in various metabolic diseases featured by lipid load, from the “rare” GSDIa to the “epidemic” morbid obesity or type 2 diabetes.Graphical abstract
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
Authors: Lajara R Abstract Chronic kidney disease (CKD) and type 2 diabetes mellitus (T2D) frequently coexist and are associated with poor clinical outcomes. Dipeptidyl peptidase-4 (DPP-4) inhibitors can be used for patients with T2D and CKD, and preclinical evidence suggests these agents may slow the progression of kidney disease in T2D. Although clinical evidence of the renal effects of DPP-4 inhibitors is limited, the recent publication of the MARLINA-T2D study provided important new data. In MARLINA-T2D, linagliptin was associated with significant improvements in glycemic control with a non-significant reductio...
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
Aim: Uromodulin is the most abundant protein excreted in urine. Low uromodulin has been found to be associated with type 2 diabetes (T2DM) as well as with chronic kidney disease (CKD). Whether it predicts a future decline in kidney function is not known and addressed in the present study.
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
Aim: Both type 2 diabetes (T2DM) and chronic kidney disease (CKD) are associated with a high risk of cardiovascular disease (CVD) and premature death. We aimed at investigating the single and joint effects of T2DM and CKD on all-cause-mortality in high-risk-patients with established CVD.
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
Aim: Uromodulin is produced exclusively by the kidneys and present in urine and blood. Low serum uromodulin has recently been demonstrated to be associated with chronic kidney disease and type 2 diabetes (T2DM). Whether serum uromodulin also predicts mortality is unknown and is addressed in the present study.
Source: Atherosclerosis - Category: Cardiology Authors: Source Type: research
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