Downregulation of tight junction protein zonula occludens-2 and urothelium damage in a cyclophosphamide-induced mouse model of cystitis

The cyclophosphamide (CYP)-induced model of cystitis in mice closely fits the symptoms of chronic bladder inflammation. Cystitis was recently found to be due to an altered gap junction protein in a rat model. Thus, this study was conducted to evaluate changes in protein expression and composition in the bladder of CYP-treated mice.

Source: Taiwanese Journal of Obstetrics and Gynecology - June 1, 2018 Category: OBGYN Authors: Yung-Hsiang Chen, Chao-Jung Chen, Shih-Jing Wang, Yu-Ning Lin, Wen-Chi Chen, Ming-Yen Tsai, Huey-Yi Chen Tags: Original Article Source Type: research