Womb transplants to give three British women hope of getting pregnant

Three women are to become the first in the UK to received a groundbreaking new womb transplant surgery which doctors believe could allow thousands of women to become mothers.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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We describe the ethical framework, logistical challenges, and rationale for the current single center (NCT03101891) and planned multicenter trial.Fetal Diagn Ther
Source: Fetal Diagnosis and Therapy - Category: Perinatology & Neonatology Source Type: research
Authors: De Vloo C, Nevens F Abstract Pruritus is a common, troublesome symptom in patients with cholestatic liver diseases, especially frequent in intrahepatic cholestasis of pregnancy (ICP) and in primary biliary cholangitis (PBC). Cholestatic associated pruritus can have profound effects on the quality of life. The underlying mechanism is still poorly understood. Severe potential pruritogens have been discussed, such as bile salts, opioids, steroid and lysophosphatidic acid (LPA), but none of these are considered as key mediators. Because of this unraveling pathophysiology the treatment of hepatogenic pruritus o...
Source: Acta Gastro-Enterologica Belgica - Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research
AbstractUnderstanding how the T cell memory response directed towards human cytomegalovirus (HCMV) develops and changes over time while the virus persists is important. Whilst HCMV primary infection and periodic reactivation is well controlled by T cell responses in healthy people, when the immune system is compromised such as post-transplantation, during pregnancy, or underdeveloped such as in new-born infants and children, CMV disease can be a significant problem. In older people, HCMV infection is associated with increased risk of mortality and despite overt disease rarely being seen there are increases in HCMV-DNA in u...
Source: Medical Microbiology and Immunology - Category: Microbiology Source Type: research
by Lina Ding, Lauren B. Shunkwiler, Nicholas W. Harper, Yang Zhao, Kunihiko Hinohara, Sung Jin Huh, Muhammad B. Ekram, Jan Guz, Michael J. Kern, Alexander Awgulewitsch, James D. Shull, Bart M. G. Smits, Kornelia Polyak Mammary epithelial progenitors are the normal cell-of-origin of breast cancer. We previously defined a population of p27+ quiescent hormone-responsive progenitor cells in the normal human breast whose frequency associates with breast cancer risk. Here, we describe that deletion of theCdkn1b gene encoding the p27 cyclin-dependent kinase inhibitor in the estrogen-induced mammary tumor-susceptible ACI rat stra...
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
With an increasing number of reproductive-aged women undergoing renal transplantation coupled with improved fertility post-transplantation, more women are becoming pregnant with a kidney transplant in place. T...
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Case report Source Type: research
Pregnancy in transplant recipients is becoming more common with improved medication regimens. Pregnancy may increase antibody production and cause stress within the mother's body leading to increase immune system response inducing changes in coronary lumen. This is a single center analysis of transplant graft vasculopathy post pregnancy at our center. No data from the transplant pregnancy registry is available on LHC and vasculopathy data. Per ISHLT report 2017 42% of all heart transplant recipients may experience graft vasculopathy within the first year post transplant.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 699 Source Type: research
Peripartum cardiomyopathy (PPCM) is a rare, but serious and potentially life-threatening condition. The nursing hormone Prolactin has been hypothesized as potential pathogenic factor of PPCM. Positive family history could be a reason for genetically caused peripartum heart failure that has possibly been demasked by the physiological pregnancy stress in a subset of patients. From animal models mutations in STAT3 may be involved in these genetic forms of PPCM.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 969 Source Type: research
THURSDAY, March 14, 2019 (American Heart Association News) -- Sarah Bradley's second pregnancy was uneventful until 30 weeks, when she found herself swollen, breathless and unusually fatigued. When her chest and left side also began to hurt a few...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
mi JM Abstract BACKGROUND AND OBJECTIVES: Thrombotic microangiopathies constitute a diagnostic and therapeutic challenge. Secondary thrombotic microangiopathies are less characterized than primary thrombotic microangiopathies (thrombotic thrombocytopenic purpura and atypical hemolytic and uremic syndrome). The relative frequencies and outcomes of secondary and primary thrombotic microangiopathies are unknown. DESIGN, SETTING, PARTICIPANTS, &MEASUREMENTS: We conducted a retrospective study in a four-hospital institution in 564 consecutive patients with adjudicated thrombotic microangiopathies during the 20...
Source: Clinical Journal of the American Society of Nephrology : CJASN - Category: Urology & Nephrology Authors: Tags: Clin J Am Soc Nephrol Source Type: research
Publication date: Available online 15 February 2019Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Emily Haesler, Nabil Melhem, Manish D. SinhaAbstractRenal disease in women of childbearing age is estimated to be approximately 3%; consequently, renal disease is not an uncommon comorbidity in pregnancy. There has been considerable evidence published over the last 20 years to suggest that renal disease in pregnancy is associated with higher maternal, fetal, and offspring morbidity. Studies published are largely heterogeneous; include unmatched cohort studies; and focus on early neonatal out...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
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