Clinical Fellow - Infectious Diseases and Aspergillosis

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Publication date: Available online 7 February 2019Source: Enzyme and Microbial TechnologyAuthor(s): Ashraf S.A. El-Sayed, Ahmed A. Shindia, Azza A. AbouZaid, Amany M. Yassin, Gul Shad Ali, Mahmoud Z. SitohyAbstractPeptidylarginine deiminases (PADs) are a group of hydrolases, mediating the deimination of peptidylarginine residues into peptidyl-citrulline. Equivocal protein citrullination by PADs of fungal pathogens has a strong relation to the progression of multiple human diseases, however, the biochemical properties of fungal PADs remain ambiguous. Thus, this is the first report exploring the molecular properties of PAD f...
Source: Enzyme and Microbial Technology - Category: Biotechnology Source Type: research
Authors: Gletsou E, Ioannou M, Liakopoulos V, Tsiambas E, Ragos V, Stefanidis I Abstract Aspergillosis, which is saprophytic in nature, is known to cause massive destruction of paranasal sinuses in immunocompromised hosts, but in immunocompetent individuals invasive aspergillosis is rare. Diagnosis is posed from history, physical examination including anterior and posterior rhinoscopy, endoscopy of the nose and paranasal sinuses, radiological findings (CT and/or MRI), fungus cultures and histopathological examination. Non-specific presenting symptoms provide time for infection to extent from sinuses to vital surrou...
Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research
Authors: Moruno-Rodríguez A, Sánchez-Vicente JL, Rueda-Rueda T, Lechón-Caballero B, Muñoz-Morales A, López-Herrero F Abstract A 30 year-old man with acute myeloblastic leukaemia and secondary myelodysplastic syndrome developed graft-versus-host disease. The patient was treated with ruxolitinib. After being treated for 3 months with ruxolitinib, an inhibitor of Janus kinase, he developed Aspergillus retinal necrosis resistant to common treatment. Treatment with Janus kinase inhibitors may lead to an increased incidence of opportunistic infections. Janus kinase inhibitor administrat...
Source: Archivos de la Sociedad Espanola de Oftalmologia - Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research
Purpose: Aspergillus species are omnipresent organisms that can be found in every region. Invasive aspergillosis infections are often found to be associated with hospital construction or renovation, which can increase the amount of airborne aspergillus, causing in high-risk patients. The severity of aspergillosis is determined by various factors. The goal of this study was to (1) examine fungal hospital-acquired infections that were detected in our facility and (2) to evaluate infection prevention and control measures in our hospital based on previous experiences, evidence and guidelines.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: 21.110 Source Type: research
Invasive aspergillosis may complicate up to 23% of HCT. Three patients with predispositions to infection with Aspergillus pre-transplant underwent reduced intensity conditioning HCT for unrelated PIDs: hypomorphic IL2R- γ deficiency (36 y/o man, P1), STAT3 mutated Hyper IgE syndrome (7 y/o girl, P2), and EBV-associated lymphoproliferative disease with mutated IκBα (30 y/o woman, P3).
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 532 Source Type: research
Publication date: Available online 25 January 2019Source: Journal de Mycologie MédicaleAuthor(s): I. Mirkov, A. Popov Aleksandrov, B. Lazovic, J. Glamoclija, M. KataranovskiAbstractAspergillosis represents a spectrum of fungal diseases which are caused by fungi of the genus Aspergillus. Animal models have been developed and used to address immune-based mechanisms of defense against these fungi. Invertebrate models enabled mass screening of virulence attributes of Aspergillus species as well as mechanisms of acquired resistance to antifungal agents. This review represents a concise view of cellular and humoral partic...
Source: Journal of Medical Mycology - Category: Biology Source Type: research
During a cross-sectional study on allergic aspergillosis in Chronic Obstructive Pulmonary Disease patients in Bogot á, Colombia, we reported the case of a 65-year-female patient with GOLD 2011 D classification, presenting dyspnea at the time of visit and aspergillus in repeated sputum cultures.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Case Report Source Type: research
Abstract APX001, the prodrug of APX001A, is a first-in-class antifungal agent that has a potent activity against Aspergillus fumigatus. The goal of current study was to determine the pharmacodynamic (PD) index and target of APX001 in an immunocompromised murine model of invasive pulmonary aspergillosis against 6 A. fumigatus isolates. Minimum effective concentration (MEC) values ranged from 0.03 to 0.06 mg/liter. Dose fractionation was performed against isolate AF293 using total doses of APX001 ranging from 81 to 768 mg/kg/day fractionated into every 3-, 6-, and 8- hourly regimens over a 96-h treatment duration. E...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Conclusions: RoutineA. fumigatus-sIgE screening for asthma patients can significantly improve the diagnostic rate of ABPA.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - Category: Allergy & Immunology Source Type: research
We report the case of a 12-year-old immunocompromised boy with spondylodiscitis of the thoracolumbar spine caused by Aspergillus terreus. Microbiologic diagnosis was confirmed by inoculation of aspiration fluid into blood culture bottles. Because of noncompliance, the patient was treated with extended voriconazole therapy (23 months) with regular serum drug concentration monitoring and intermittent direct observation therapy in an outpatient clinic. The Aspergillus genus contains species that are important causes of morbidity and mortality in immunocompromised hosts. Although the lung is the main target of invasive Aspergi...
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Immunology Reports Source Type: research
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