Chromosomal Aberrations and Survival after Unrelated Donor Hematopoietic Stem Cell Transplant in Patients with Fanconi Anemia
• Gains of chromosome 1q and 3q and deletion of 7q or monosomy 7 were the most frequently detected aberrations in pre-HCT blood samples of patients with Fanconi Anemia (FA).• Gains of chromosome 3q, and aberrations in 3 or more chromosomes in patients with FA were associated with poor survival a fter unrelated donor HCT.• Post-HCT survival in patients with deletion of 7q or monosomy 7 was not significantly worse than in patients without those aberrations.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Youjin Wang, Weiyin Zhou, Blanche P. Alter, Tao Wang, Stephen R. Spellman, Michael Haagenson, Meredith Yeager, Stephanie J. Lee, Stephen J. Chanock, Sharon A. Savage, Shahinaz M. Gadalla Source Type: research
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