Patched-2 functions to limit Patched-1 deficient skin cancer growth

ConclusionsWe conclude that like Ptch1, Ptch2 exerts a tumor-suppressive function in BCC cells, and that after targeting of both paralogs, ligand-independent activation of the Hh pathway contributes to tumor growth.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research